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Mozaffarieh, M; Heinzl, H; Sacu, S; Wedrich, A.
In-patient management and treatment satisfaction after intravitreous plasminogen activator injection.
Graefes Arch Clin Exp Ophthalmol. 2006; 244(11):1421-1428 Doi: 10.1007/s00417-005-0232-z
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Führende Autor*innen der Med Uni Graz: Wedrich Andreas
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Abstract:: AIMS: To assess patient satisfaction after intravitreous plasminogen activator injections for subretinal hemorrhages secondary to age-related macular degeneration (AMD) and to analyse how it relates to the patients' postoperative visual and functional abilities. Further, to suggest ways to improve in-patient management and thereby treatment satisfaction. METHODS: A consecutive series of 101 patients with a subretinal hemorrhage of at least one disk diameter were enrolled in this longitudinal prospective study conducted during 2001-2004. After complete preoperative eye examination all patients were treated with intravitreal injection of 25 microg recombinant tissue plasminogen activator (rTPA) and 0.5 ml sulphur hexafluoride gas (SF6), followed by face-down positioning for 1 week. Patient satisfaction was assessed using standardised questionnaires administered postoperatively at 4 and 12 months. Outcome measures were: (1) responses to the patient satisfaction survey, (2) degree of satisfaction with in-patient management, (3) subjective change in the patients' functional status, and (4) visual acuity results. RESULTS: Whereas the patients' actual functional status deteriorated from a median value of 2.4 at 4 months to 3.4 at 12 months, their recall of their preoperative functional status shifted from a median value of 4.2 to to 2.3, consecutively. Twelve months after treatment, 75% of patients reported an improved visual acuity, however, only 12% reported satisfaction with treatment. 67.4-87% of patients were dissatisfied with various areas of in-patient management. CONCLUSIONS: Satisfaction with plasminogen activator injection treatment is low even though patients experience an improved visual and functional status at 12 months. This suggests that the current system requires improvement in certain areas such as in-patient management.
Find related publications in this database (using NLM MeSH Indexing): Drug Therapy, Combination -; Fibrinolytic Agents - administration and dosage; Follow-Up Studies - administration and dosage; Humans - administration and dosage; Injections - administration and dosage; Inpatients - administration and dosage; Macular Degeneration - complications; Patient Satisfaction - complications; Prone Position - complications; Prospective Studies - complications; Questionnaires - complications; Recombinant Proteins - administration and dosage; Retinal Hemorrhage - drug therapy; Sulfur Hexafluoride - administration and dosage; Tissue Plasminogen Activator - administration and dosage; Visual Acuity - physiology; Vitreous Body - physiology
Find related publications in this database (Keywords): intravetreous injection; plasminogen activator injection; subretinal hemmorhage; age-related macular degeneration; patients' satisfaction