Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Oberhuber, G; Kastner, N; Stolte, M.
Giardiasis: a histologic analysis of 567 cases.
Scand J Gastroenterol. 1997; 32(1): 48-51.
Doi: 10.3109/00365529709025062
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Kastner Norbert
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- Abstract:
- BACKGROUND: The histopathology of the upper and lower gastrointestinal tract of patients with giardiasis as shown by endoscopy with biopsy is ill-defined. We therefore report on 567 cases observed in our institution. METHODS: A retrospective analysis of all cases with giardiasis observed between 1988 and 1994 was performed. RESULTS: On histologic slides trophozoites were found in duodenal (82.5%) and jejunal (2.1%) mucosa and also in gastric antral (8.7%) and ileal mucosa (12.1%) but rarely in the colon (0.4%). An entirely normal light-microscopic appearance of the duodenal mucosa was found in 462 cases (96.3%). Mild villous shortening and mild inflammation of the lamina propria were observed in duodenal mucosa in 18 subjects (3.7%). In jejunal, ileal, gastric, and colonic mucosa, no Giardia-specific histologic changes were identified. There was a clear male predominance with 347 (61.2%) males and 220 (38.8%) females. Mean age, which was comparable in males and females, was 49.5 +/- 17 years (range, 3-95 years). In 252 Giardia-positive cases gastric biopsy specimens were available, and showed Helicobacter pylori-associated gastritis in 57.8%, reactive gastritis in 10.3%, normal mucosa in 12.9%, chronic atrophic gastritis of the body in 2.9%, and other forms of gastritis in 16.1%. CONCLUSIONS: This study shows that the histology of the small-bowel mucosa is inconspicuous in most subjects with giardiasis. A search for the parasite must therefore be made in all biopsy samples obtained from this area. Furthermore, giardiasis was not associated with a particular gastric disease, such as chronic atrophic gastritis of the body.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Biopsy -
- Child -
- Child, Preschool -
- Diagnosis, Differential -
- Digestive System - parasitology
- Female - parasitology
- Gastritis - complications
- Giardiasis - complications
- Helicobacter Infections - complications
- Helicobacter pylori - complications
- Humans - complications
- Intestinal Mucosa - parasitology
- Male - parasitology
- Middle Aged - parasitology
- Retrospective Studies - parasitology
- Sex Factors - parasitology
- Find related publications in this database (Keywords)
- Giardia lamblia
- histology
- ileum
- stomach