Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Peris, K; Cerroni, L; Chimenti, S; Soyer, HP; Kerl, H; Höfler, H.
Analysis of point mutations of Ha-ras gene in basaliomas and spinaliomas usiang the polymerase chain reaction (PCR) technic
G Ital Dermatol Venereol. 1989; 124(10): 429-434.
PubMed
- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Kerl Helmut
- Soyer Hans Peter
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- Abstract:
- Polymerase chain reaction is a recently developed procedure to detect point mutations in human genomic DNA. The sensitivity and specificity of this technique which requires a very little amount of DNA, have allowed the large scale screening of tumors. The Authors report the detection of point mutations of Ha-ras gene at codon 12 in 12 basal cell carcinomas and 10 cutaneous squamous cell carcinomas by the use of polymerase chain reaction in paraffin-embedded tissue sections. The gene alteration was identified in 2 basaliomas whereas no squamous cell carcinoma showed point mutations. These results suggest that point mutations of Ha-ras gene do not represent a general activating mechanism in cutaneous epitheliomas.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Basal Cell - genetics
- Carcinoma, Squamous Cell - genetics
- Codon - genetics
- English Abstract - genetics
- Humans - genetics
- Mutation - genetics
- Polymerase Chain Reaction - genetics
- Skin Neoplasms - genetics