Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lassmann, H; Petsche, U; Kitz, K; Baran, H; Sperk, G; Seitelberger, F; Hornykiewicz, O.
The role of brain edema in epileptic brain damage induced by systemic kainic acid injection.
Neuroscience. 1984; 13(3):691-704
Doi: 10.1016/0306-4522(84)90089-7
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- Co-Autor*innen der Med Uni Graz
- Holzer Ulrike
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- Abstract:
- Edema formation and blood-brain barrier permeability was studied in animals with epileptic seizures induced by subcutaneous injection of kainic acid. Brain edema was most pronounced between 3 and 24 h after kainic acid injection. It was reflected by massive swelling of perineuronal and perivascular astroglia. Three hours after kainic acid perivascular astroglia swelling resulted in disturbance of local microcirculation in the affected brain areas. In addition, compression of drainage veins by the edematous brain induced focal perivenous hemorrhages similar to herniation damage in human brain edema. Tracer studies with sodium fluorescein, Evans blue, albumin and horseradish peroxidase revealed only a mild increase in the permeability of cerebral vessels, topographically unrelated to areas of brain edema. This finding indicates the presence of cytotoxic brain edema in kainic acid-induced epileptic brain damage. Treatment of brain edema with dexamethasone did not influence the incidence and severity of kainic acid-induced epileptic brain damage. However, in 54% of animals injected with kainic acid, lesions were completely prevented by treatment of brain edema with mannitol. The present results indicate that brain edema plays an important role in the pathogenesis of epileptic brain damage following systemic kainic acid intoxication. It is suggested that in this model of limbic epilepsy the brain edema is due to the massive ionic imbalance elicited in the affected brain regions by the kainic acid-induced persistent neuronal excitation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood-Brain Barrier - drug effects
- Brain Edema - chemically induced
- Convulsants - pharmacology
- Epilepsy - chemically induced
- Kainic Acid - pharmacology
- Male - pharmacology
- Pyrrolidines - pharmacology
- Rats - pharmacology
- Rats, Inbred Strains - pharmacology
- Research Support, Non-U.S. Gov't - pharmacology