Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Welk, E; Petsche, U; Fleischer, E; Handwerker, HO.
Altered excitability of afferent C-fibres of the rat distal to a nerve site exposed to capsaicin.
Neurosci Lett. 1983; 38(3):245-250
Doi: 10.1016/0304-3940(83)90376-2
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- Co-Autor*innen der Med Uni Graz
- Holzer Ulrike
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- Abstract:
- Excitability of afferent C-fibres in saphenous and coccygeal nerves of rats was studied distal to a nerve site treated with 1% capsaicin for half an hour one day before. This treatment induced the following changes. (a) Fewer C-fibres than in control nerves were excited by natural skin stimulation among those driven by electrical nerve stimulation. Comparison of compound action potentials derived from capsaicin-treated and from untreated contralateral coccygeal nerves indicated that the total number of excitable C-fibres was also diminished. (b) Whereas in a normal rat nerve virtually all unmyelinated nociceptors responding to heat stimulation are also driven by strong mechanical stimuli (MH-nociceptors, polymodal nociceptors), most of them were found to respond only to heat stimulation after local capsaicon treatment of the nerve.
- Find related publications in this database (using NLM MeSH Indexing)
- Action Potentials - drug effects
- Afferent Pathways - drug effects
- Animals - drug effects
- Axonal Transport - drug effects
- Capsaicin - pharmacology
- Comparative Study - pharmacology
- Electric Stimulation - pharmacology
- Heat - pharmacology
- Nerve Fibers - drug effects
- Neurotransmitter Agents - metabolism
- Nociceptors - drug effects
- Physical Stimulation - drug effects
- Rats - drug effects
- Rats, Inbred Strains - drug effects
- Research Support, Non-U.S. Gov't - drug effects
- Sacrococcygeal Region - innervation
- Skin - innervation