Medizinische Universität Graz - Research portal
Selected Publication:
Holzer, P; Holzer-Petsche, U.
Tachykinin receptors in the gut: physiological and pathological implications.
Curr Opin Pharmacol. 2001; 1(6): 583-590.
Doi: 10.1016/S1471-4892(01)00100-X
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- Leading authors Med Uni Graz
- Holzer Peter
- Co-authors Med Uni Graz
- Holzer Ulrike
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- Abstract:
- The tachykinins substance P and neurokinin A participate in the regulation of gastrointestinal motility, secretion, vascular permeability and pain sensitivity. Advances made during the past two years corroborate a causal involvement of tachykinins in inflammation-induced disturbances of gut function, such as dysmotility, secretory diarrhoea, oedema and hyperalgesia. It would therefore appear that tachykinin receptors, which in the digestive system are expressed in a cell-specific manner, represent attractive targets for novel therapeutics in gastroenterology.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Colonic Diseases, Functional - drug therapy
- Digestive Physiology - drug therapy
- Digestive System - metabolism
- Gastrointestinal Diseases - drug therapy
- Gastrointestinal Motility - drug therapy
- Humans - drug therapy
- Inflammatory Bowel Diseases - drug therapy
- Neurokinin A - metabolism
- Receptors, Neurokinin-1 - metabolism
- Receptors, Neurokinin-2 - metabolism
- Receptors, Neurokinin-3 - metabolism
- Receptors, Tachykinin - antagonists and inhibitors
- Research Support, Non-U.S. Gov't - antagonists and inhibitors
- Substance P - metabolism