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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Groschner, K; Rosker, C.
TRPC3: a versatile transducer molecule that serves integration and diversification of cellular signals.
Naunyn Schmiedebergs Arch Pharmacol. 2005; 371(4):251-256
Doi: 10.1007/s00210-005-1054-6
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- Leading authors Med Uni Graz
- Groschner Klaus
- Co-authors Med Uni Graz
- Rosker Christian
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- Abstract:
- Transient receptor potential (TRP) proteins have been recognized as sensors for a wide variety of external and internal signals involved in maintenance of cellular homeostasis and control of physiological functions. Evidence of a striking versatility in terms of signal integration and transduction has been reported for members of the canonical (or classical) TRP subfamily (TRPCs). TRPC species are cation channel subunits and emerge as multifunctional signal transduction molecules that are able to function as components of divergent signalplexes. Results obtained in heterologous expression systems suggest TRPC3 as a paradigm of multifunctional signal transduction by a cation channel protein. TRPC3 serves cellular Ca(2+) signaling by multiple mechanisms and may control a variety of distinct physiological functions. In this review, we summarize current knowledge on the properties and possible signaling partners of TRPC3, and discuss the role of TRPC3 channel proteins in cellular signaling networks.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium Signaling - physiology
- Cell Line -
- Humans -
- Ion Channel Gating - physiology
- TRPC Cation Channels - metabolism TRPC Cation Channels - physiology
- Find related publications in this database (Keywords)
- TRPC proteins
- Non-selective cation channels
- Capacitative Ca2+ stop entry channels
- Heteromultimerization
- Phospholipase C
- Na+ stop
- Ca2+ stop exchange
- Redox signaling
- Lipid rafts