Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Groschner, K; Rosker, C; Lukas, M.
Role of TRP channels in oxidative stress.
Novartis Found Symp. 2004; 258(2):222-230
Doi: 10.1002/0470862580.ch16
PubMed
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- Führende Autor*innen der Med Uni Graz
- Groschner Klaus
- Co-Autor*innen der Med Uni Graz
- Rosker Christian
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- Abstract:
- Increasing evidence suggests a pivotal role of reactive oxygen species (ROS) as well as reactive nitrogen species (RNS) in human pathophysiology. A typical target of ROS/RNS signalling is Ca2+ channels which mediate both long-term as well as acute cellular responses to oxidative stress. We have previously reported that cation channels related to the Drosophila transient receptor potential gene product (TRPC proteins) are likely to serve as redox sensors in the vascular endothelium, and demonstrated that TRPC3 expression is a determinant of the nitric oxide sensitivity of store-operated Ca2+ signalling. Experiments with TRPC species overexpressed in HEK293 cells confirmed that TRPC3 and TRPC4 are able to form redox sensitive cation channels. A key mechanism involved in redox activation of TRPC3 appears to be ROS-induced promotion of protein tyrosine phosphorylation and stimulation of phospholipase C activity. In addition, oxidative stress-induced disruption of caveolin 1-rich lipid raft domains, which interfere with functional TRPC channels, is likely to contribute to redox modulation of TRP proteins and to oxidative stress-induced changes in cellular Ca2+ signalling. Taken together, our data suggest TRPC species serve as a link between cellular redox state and Ca2+ homeostasis. Thus, modulation of these cellular redox sensors may offer unique opportunities for therapeutic interventions.
- Find related publications in this database (using NLM MeSH Indexing)
- Calcium - physiology
- Calcium Signaling - physiology
- Caveolin 1 -
- Caveolins - metabolism
- Cells, Cultured -
- Cholesterol - metabolism
- Endothelial Cells - metabolism
- Humans -
- Ion Channels - chemistry Ion Channels - genetics Ion Channels - metabolism
- Oxidation-Reduction -
- Oxidative Stress -
- Peroxides - pharmacology
- Sodium - metabolism
- TRPC Cation Channels -
- Type C Phospholipases - pharmacology