Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Augustin, H; Auprich, M; Stummvoll, P; Lipsky, K; Pummer, K; Petritsch, P.
Shift of tumor features in patients with clinically localized prostate cancer undergoing radical prostatectomy since the beginning of the PSA era.
Wien Klin Wochenschr. 2006; 118(11-12):348-354
Doi: 10.1007/s00508-006-0608-z
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Augustin Herbert
- Co-Autor*innen der Med Uni Graz
- Auprich Marco
- Lipsky Katja
- Petritsch Peter
- Pummer Karl
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- Abstract:
- Aim: To analyze trends of clinical and tumor characteristics over a 12-year period since the beginning of the prostate-specific antigen (PSA) era in a consecutive series of radical prostatectomies. Patients and methods: Between 1993 and 2004 a consecutive series of 1351 patients underwent radical prostatectomy for clinically localized prostate cancer (PC) in a single institution. Clinical and histopathological information was entered into our computer database and analyzed for changes over time. Results: The annual frequency of surgical interventions increased from 43 to 160 (272%) during the observation period (r = 0.930; p < 0.01). The detection of PC based solely on pathological PSA levels rose impressively from 7% to 70% (r = 0.986; p < 0.01). The rates of organ-confined disease also increased significantly from 47% to 79% (r=0.774; p < 0.01). Stage pT3a decreased somewhat from 28% to 18% (r = -0.389; n.s.) whereas pT3b decreased significantly from 26% to 3% (r = -0.729; p < 0.01). Conclusion: During the 12-year period, PC was increasingly detected on the basis of a pathological PSA level only and shifted significantly to more organ-confined stages. With a time delay, these findings are consistent with trends observed in large centers in the USA.
- Find related publications in this database (using NLM MeSH Indexing)
- - epidemiology
- Humans -
- Male -
- Middle Aged -
- Neoplasm Staging - trends
- Prostate-Specific Antigen - blood
- Prostatectomy - statistics & numerical data
- Prostatic Neoplasms - blood
- Treatment Outcome -
- Find related publications in this database (Keywords)
- prostate cancer
- radical prostatectomy
- stage migration
- PSA
- pT0