Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

Kenner, L; el-Shabrawi, Y; Hutter, H; Forstner, M; Zatloukal, K; Hoefler, G; Preisegger, KH; Kurzbauer, R; Denk, H.
Expression of three- and four-repeat tau isoforms in mouse liver.
Hepatology. 1994; 20(4 Pt 1):1086-1089 Doi: 10.1002/hep.1840200442
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Denk Helmut; Kenner Lukas
Co-authors Med Uni Graz: El-Shabrawi Yosuf; Höfler Gerald; Hutter Heinz; Preisegger Karl Heinz; Zatloukal Kurt
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Tau protein is a member of the family of microtubule-associated proteins, which support microtubule polymerization and stability. Under pathological conditions, tau is a major constituent of neurofibrillary tangles in nerve cells of patients with Alzheimer's disease. Neurofibrillary tangles share some morphological, biochemical and immunological properties with cytoplasmic inclusions associated with other diseases, such as Mallory bodies in the livers of patients with alcoholic hepatitis and in corresponding mouse models. Recently a Mallory body component was identified that in molecular mass and isoelectric point resembles the abnormally phosphorylated tau of neurofibrillary tangles. There has been, however, so far no report describing the occurrence of tau in normal liver. We now demonstrate the expression of two tau isoforms containing three and four repeats, respectively, of the microtubule-binding domains in normal mouse liver and kidney. This finding provides evidence for a physiological role of tau in the liver and, consequently, the basis for the involvement of tau in pathological situations.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Base Sequence -; Blotting, Northern -; Brain - metabolism; Isomerism - metabolism; Kidney - metabolism; Liver - metabolism; Male - metabolism; Mice - metabolism; Microtubules - metabolism; Molecular Sequence Data - metabolism; Polymerase Chain Reaction - metabolism; RNA, Messenger - metabolism; Repetitive Sequences, Nucleic Acid - metabolism; tau Proteins - genetics