Medizinische Universität Graz - Research portal
Selected Publication:
Simma, B; Meister, B; Deutsch, J; Sperl, W; Fend, F; Ofner, D; Margreiter, R; Vogel, W.
Fulminant hepatic failure in a child as a potential adverse effect of trimethoprim-sulphamethoxazole.
Eur J Pediatr. 1995; 154(7):530-533
Doi: 10.1007%2Fs004310050336
(- Case Report)
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- Co-authors Med Uni Graz
- Deutsch Johann
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- Abstract:
- Trimethoprim-sulphamethoxazole (TMP-SMZ) is considered a safe drug for treatment of infectious bacterial diseases in children. Side-effects are rare and generally take the form of a hypersensitivity reaction to the sulphamethoxazole component of the drug. Hepatic injury usually presents as a transient elevation of liver enzymes, which is of little clinical relevance. Fulminant liver failure due to TMP-SMZ has been reported in only six adults and never in children. We here report a 5-year-old girl who developed fulminant liver failure 3 weeks after her third exposure to TMP-SMZ. After a biphasic clinical course she underwent successful liver transplantation. CONCLUSION: Trimethoprim-Sulphamethoxazole may cause fulminant liver failure in children. The disease can run a biphasic clinical course and liver transplantation must be considered as the therapeutic option for these patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Biopsy -
- Child, Preschool -
- Escherichia coli Infections - drug therapy
- Female - drug therapy
- Hepatic Encephalopathy - chemically induced
- Humans - chemically induced
- Liver - pathology
- Liver Function Tests - pathology
- Liver Transplantation - pathology
- Recurrence - pathology
- Trimethoprim-Sulfamethoxazole Combination - administration and dosage
- Urinary Tract Infections - drug therapy
- Find related publications in this database (Keywords)
- Trimethoprim-Sulfamethoxazole
- Fulminant Liver Failure
- Child Liver Transplantation