Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Giuliani, A; Schoell, W; Auner, J; Urdl, W.
Controlled ovarian hyperstimulation in assisted reproduction: effect on the immune system.
Fertil Steril. 1998; 70(5):831-835
Doi: 10.1016%2FS0015-0282%2898%2900282-9
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Giuliani Albrecht
- Co-Autor*innen der Med Uni Graz
- Auner Johann
- Schöll Wolfgang
- Urdl Wolfgang
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- Abstract:
- OBJECTIVE: To determine how controlled ovarian hyperstimulation (COH) in assisted reproduction affects the immune system. DESIGN: A prospective, nonrandomized, case-control study. SETTING: Academic research setting. PATIENT(S): Women with regular menstrual cycles undergoing COH in an assisted reproduction program. INTERVENTION(S): Blood samples were collected in the early and late follicular phase, at the time of ovulation, and in the luteal phase during a natural cycle, and at four times during the next cycle, which included COH and IVF. MAIN OUTCOME MEASURE(S): Lymphocyte subpopulations and the differential blood count. RESULT(S): In the natural cycles, a significant increase in the total numbers of lymphocytes, B cells, natural killer cells, and CD3+HLADR+ cells was observed in the late follicular phase, whereas the T helper/T suppressor cell ratio declined. In the hyperstimulated cycles, increases were seen in the total numbers of leukocytes and neutrophils on the day of hCG administration; the number of lymphocytes, monocytes, and neutrophils was increased on the day of oocyte retrieval, and the total number of leukocytes and neutrophils increased during the luteal phase. CONCLUSION(S): Controlled ovarian hyperstimulation with hMG and simultaneous administration of a GnRH antagonist did not affect the immune system.
- Find related publications in this database (using NLM MeSH Indexing)
- Case-Control Studies -
- Embryo Transfer -
- Female -
- Fertilization in Vitro -
- Follicular Phase - immunology
- Humans - immunology
- Immune System - immunology
- Luteal Phase - immunology
- Ovarian Hyperstimulation Syndrome - immunology
- Ovulation - immunology
- Find related publications in this database (Keywords)
- Controlled Ovarian Hyperstimulation
- Human Menopausal Gonadotropin
- Gonadotropin-Releasing Hormone Antagonist
- Lymphocyte Subsets