Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Resch, B; Gusenleitner, W; Müller, WD.
Procalcitonin and interleukin-6 in the diagnosis of early-onset sepsis of the neonate.
Acta Paediatr. 2003; 92(2):243-245
Doi: 10.1097%2F00006454-200305000-00024
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Resch Bernhard
- Co-Autor*innen der Med Uni Graz
- Gusenleitner Walter
- Müller Wilhelm
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- Abstract:
- The reliability of procalcitonin (PCT) and interleukin-6 (IL-6) was determined and compared with that of C-reactive protein (CRP) in the diagnosis of early-onset sepsis of the neonate within the first 12 h of life. ROC analysis of values of 41 neonates with blood-cultures-positive and clinical sepsis compared with those of 27 uninfected neonates revealed sensitivities for PCT (> or = 6 ng/mL), IL-6 (> or = 60 pg/mL), and CRP (> or = 2.5 mg/L) of 77%, 54%, and 69% and specificities of 91%, 100% and 96%, respectively. Sensitivity of CRP at > or = 8 mg/L was 49% (p = 0.012 compared to PCT). CONCLUSION: PCT was the most sensitive diagnostic parameter in the diagnosis of early-onset sepsis within 12 h of life.
- Find related publications in this database (using NLM MeSH Indexing)
- Birth Weight -
- C-Reactive Protein - analysis
- Calcitonin - blood
- Gestational Age - blood
- Humans - blood
- Infant, Newborn - blood
- Interleukin-6 - blood
- Predictive Value of Tests - blood
- Protein Precursors - blood
- ROC Curve - blood
- Reproducibility of Results - blood
- Sensitivity and Specificity - blood
- Sepsis - blood
- Time Factors - blood
- Find related publications in this database (Keywords)
- C-reactive protein
- early-onset sepsis
- interleukin-6
- neonate
- procalcitonin