Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Benesch, M; Deeg, HJ.
Hematopoietic cell transplantation for adult patients with myelodysplastic syndromes and myeloproliferative disorders.
MAYO CLIN PROC. 2003; 78(8): 981-990.
Doi: 10.4065/78.8.981
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
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- Abstract:
- Hematopoietic cell transplantation (HCT) is currently the only treatment with curative potential for myelodysplastic syndromes (MDS) and myeloproliferative disorders (MPD). Among patients with less advanced MDS, 3-year survival rates of 65% to 75% are achieved with HLA-identical related and unrelated donors. The probability of relapse is less than 5%. Among patients with advanced MDS (> or = 5% marrow blasts), about 35% to 45% who receive transplants from related donors and 25% to 30% who receive transplants from unrelated donors are in remission beyond 3 years. The incidence of posttransplantation relapse is 10% to 35%. Criteria of the International Prognostic Scoring System (originally developed for nontransplant patients) also predict relapse and survival after HCT. Transplantation is successful in 50% to 80% of patients with MPD if performed before leukemic transformation. Depending on the individual risk profile, a considerable number of patients with MDS or MPD are cured by allogeneic HCT. However, HCT should be performed before disease progression. Outcome of patients with treatment-related MDS or with relapse after transplantation remains poor. At present, no definite conclusions can be made with regard to reduced-intensity transplantation regimens.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Chronic Disease -
- Disease Progression -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Myelodysplastic Syndromes - therapy
- Myeloproliferative Disorders - therapy
- Recurrence - therapy
- Risk - therapy
- Survival Analysis - therapy