Medizinische Universität Graz - Research portal
Selected Publication:
Felsner, P; Hofer, D; Rinner, I; Mangge, H; Gruber, M; Korsatko, W; Schauenstein, K.
Continuous in vivo treatment with catecholamines suppresses in vitro reactivity of rat peripheral blood T-lymphocytes via alpha-mediated mechanisms.
J Neuroimmunol. 1992; 37(1-2):47-57
Doi: 10.1016/0165-5728(92)90154-D
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Schauenstein Konrad
- Co-authors Med Uni Graz
- Mangge Harald
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- A 20 h continuous treatment of rats with catecholamines, using subcutaneously implantable retard tablets, had either no (adrenaline, isoproterenol, midodrine) or a slight (noradrenaline) suppressive effect on the in vitro responsiveness of peripheral blood T-lymphocytes. A marked suppression of the mitogen response ensued when adrenaline, noradrenaline or midodrine, but not isoproterenol, was applied together with the beta-receptor blocker propranolol, whereas the combination with the alpha-receptor blocker phentolamine had no effect. The mitogen response of splenic lymphocytes was not affected by any of these treatments. This alpha-mediated adrenergic suppression of peripheral blood T-cells was not correlated with general metabolic alterations, shifts in white blood cell counts or CD4+/CD8+ subsets, or with elevated glucocorticoid levels. The data suggest that to consistently influence the reactivity of rat peripheral blood lymphocytes by chronic adrenergic stimuli in vivo requires both high catecholamine levels and a bias towards alpha-adrenergic receptivity.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Cells - physiology
- Corticosterone - blood
- Epinephrine - pharmacology
- Isoproterenol - pharmacology
- Leukocyte Count - drug effects
- Lymphocyte Subsets - drug effects
- Male -
- Midodrine - pharmacology
- Norepinephrine - pharmacology
- Propranolol - pharmacology
- Rats -
- Rats, Inbred Strains -
- Receptors, Adrenergic, alpha - physiology
- Stress, Physiological - blood
- Sympathomimetics - pharmacology
- T-Lymphocytes - drug effects T-Lymphocytes - physiology
- Find related publications in this database (Keywords)
- Catecholamine
- Alpha-Adrenergic Receptor
- Mitogen Response
- Lymphocyte-T