Medizinische Universität Graz - Research portal
Selected Publication:
Pickel, H; Lahousen, M; Petru, E; Stettner, H; Hackl, A; Kapp, K; Winter, R.
Consolidation radiotherapy after carboplatin-based chemotherapy in radically operated advanced ovarian cancer.
Gynecol Oncol. 1999; 72(2):215-219
Doi: 10.1006/gyno.1998.5184
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- Co-authors Med Uni Graz
- Hackl Arnulf
- Kapp Karin S.
- Lahousen Manfred
- Petru Edgar
- Winter Raimund
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- Abstract:
- The aim of the study was to evaluate the effect of additional radiotherapy after chemotherapy on the relapse-free and overall survival rates of patients with advanced ovarian cancer. Between 1985 and 1992 64 patients with radically operated ovarian cancers (4 stage IC, 2 stage II, 54 stage III, and 4 stage IV) were enrolled in a randomized study. Radical surgery comprised total abdominal hysterectomy and bilateral salpingo-oophorectomy, omentectomy, and pelvic and paraaortic lymphadenectomy. All patients received adjuvant chemotherapy with carboplatin IV 400 mg/m2, epirubicin IV 70 mg/m2 on day 1 and prednimustine orally 100 mg/m2 on days 3 to 7 at 1-month intervals. Thirty-two patients without residual disease were randomized to whole abdominal radiation (30 Gy, administered over 4 weeks). An additional 21.6 Gy were delivered to the pelvis and 12 Gy to the paraaortic region up to the diaphragm for total doses of 51.6 and 42 Gy, respectively. Cancer-related survival was calculated with the Kaplan-Meier and Cox proportional hazards methods. The relapse-free and overall survival rates of patients who received adjuvant chemoradiotherapy were significantly higher than those of patients who received adjuvant chemotherapy only (68% vs 56% at 2 years and 49% vs 26% at 5 years, P = 0.013, and 87% vs 61% at 2 years and 59% vs 33% at 5 years, P = 0.029). The differences were most pronounced in patients with stage III disease (77% vs 54% at 2 years and 45% vs 19% at 5 years, P = 0. 0061, and 88% vs 58% at 2 years and 59% vs 26% at 5 years, P = 0. 012). Toxicities were acceptable. Sequential combination of platinum-based chemotherapy with open-field abdominal radiotherapy is a promising adjuvant regimen for patients with advanced ovarian cancer. Copyright 1999 Academic Press.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Carboplatin - administration & dosage
- Combined Modality Therapy -
- Disease-Free Survival -
- Epirubicin - administration & dosage
- Female -
- Follow-Up Studies -
- Humans -
- Middle Aged -
- Ovarian Neoplasms - drug therapy
- Ovarian Neoplasms - mortality
- Ovarian Neoplasms - radiotherapy
- Ovarian Neoplasms - surgery
- Prednimustine - administration & dosage
- Radiotherapy, Adjuvant -
- Survival Rate -
- Find related publications in this database (Keywords)
- Ovarian Cancer
- Advanced Stages
- Radical Surgery
- Lymphadenectomy
- Chemoradiotherapy