Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Magnet, MK; Bonelli, RM; Kapfhammer, HP.
Amantadine in the akinetic-rigid variant of Huntington's disease.
ANN PHARMACOTHER. 2004; 38(7-8): 1194-1196.
Doi: 10.1345/aph.1E004
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Bonelli Raphael
- Magnet Markus Konrad
- Co-Autor*innen der Med Uni Graz
- Kapfhammer Hans-Peter
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVE: To report the effects of amantadine on an akinetic-rigid variant of Huntington's disease (HD). CASE SUMMARY: We describe a 36-year-old woman with HD who was treated with intravenous amantadine for 5 days. The woman was evaluated with the Unified Huntington's Disease Rating Scale before and after treatment. Parkinsonism, bradykinesia, and dystonia improved significantly. DISCUSSION: Amantadine is a noncompetitive N-methyl d-aspartate receptor antagonist. It is mainly used in the treatment of Parkinson's disease, as it increases dopamine levels in the brain. This effect is said to ameliorate akinesia. Although the effect of amantadine on choreatic dystonia in HD has been reported in several studies, to the best of our knowledge, this is the first report of the ameliorative effects of amantadine on the rigid form of HD. Our patient showed improvements of gait, parkinsonism, and dystonia. Fine-motor tasks and eye movement did not change significantly. CONCLUSIONS: We suggest that amantadine treatment might be of value to patients with the akinetic-rigid variant of HD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Amantadine - therapeutic use
- Antiparkinson Agents - therapeutic use
- Female - therapeutic use
- Humans - therapeutic use
- Huntington Disease - drug therapy
- Find related publications in this database (Keywords)
- amantadine
- Huntington's disease
- akinetic-rigid variant