Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stevens, B; Porta, S; Haak, LL; Gallo, V; Fields, RD.
Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials.
Neuron. 2002; 36(5):855-868
Doi: 10.1016%2FS0896-6273%2802%2901067-X
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Porta Sepp
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Neuronal activity influences myelination of the brain, but the molecular mechanisms involved are largely unknown. Here, we report that oligodendrocyte progenitor cells (OPCs) express functional adenosine receptors, which are activated in response to action potential firing. Adenosine acts as a potent neuron-glial transmitter to inhibit OPC proliferation, stimulate differentiation, and promote the formation of myelin. This neuron-glial signal provides a molecular mechanism for promoting oligodendrocyte development and myelination in response to impulse activity and may help resolve controversy on the opposite effects of impulse activity on myelination in the central and peripheral nervous systems.
- Find related publications in this database (using NLM MeSH Indexing)
- Action Potentials - physiology
- Adenosine - metabolism
- Adenosine Triphosphate - metabolism
- Animals - metabolism
- Apoptosis - physiology
- Calcium - metabolism
- Cell Differentiation - physiology
- Cell Lineage - physiology
- Central Nervous System - physiology
- Electric Stimulation - physiology
- Ganglia, Spinal - cytology
- Mice - cytology
- Mice, Transgenic - cytology
- Myelin Sheath - physiology
- Neurons - drug effects
- Oligodendroglia - drug effects
- Rats - drug effects
- Receptors, Purinergic P1 - genetics
- Stem Cells - drug effects