Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Follesa, P; Cagetti, E; Porta, S; Espositoto, G; Biggio, G.
Pivagabine-induced increases in the abundance of CRF mRNA in the cerebral cortex and hypothalamus of rats.
Brain Res Mol Brain Res. 2000; 84(1-2):52-57
Doi: 10.1016%2FS0169-328X%2800%2900209-6
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- Co-Autor*innen der Med Uni Graz
- Porta Sepp
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- Abstract:
- The effect of treatment of rats with pivagabine (4-[(2,2-dimethyl-1-oxopropyl) amino] butanoic acid) for 4 days on the abundance of corticotropin-releasing factor (CRF) mRNA in the brain was investigated. Such treatment resulted in dose-dependent (100-300 mg/kg, i.p.) increases in the amount of CRF mRNA in both the hypothalamus and cerebral cortex. The maximal increases were thus apparent with the dose of 300 mg/kg in the hypothalamus (+108%) and cerebral cortex (+49%) 30 or 60 min, respectively, after the last drug injection. Foot-shock stress administered 30 min after the final drug injection had no effect on the pivagabine-induced increases in the abundance of CRF mRNA in the hypothalamus or cerebral cortex. Such stress also had no effect on the amounts of CRF mRNA in these brain regions of vehicle-treated rats. These results demonstrate that pivagabine increases the amount of CRF mRNA in both the hypothalamus and cerebral cortex of rats, effects that might be relevant to the action of this drug in preventing the stress-induced changes in CRF hypothalamic concentration.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anticonvulsants - pharmacology
- Cerebral Cortex - drug effects
- Corticotropin-Releasing Hormone - genetics
- Electroshock - genetics
- Gene Expression Regulation - drug effects
- Hypothalamus - drug effects
- Male - drug effects
- Psychotropic Drugs - pharmacology
- RNA, Messenger - genetics
- Rats - genetics
- Rats, Sprague-Dawley - genetics
- Stress - physiopathology
- gamma-Aminobutyric Acid - analogs and derivatives
- Find related publications in this database (Keywords)
- stress
- hypothalamic-pituitary-adrenal
- gene expression