Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Taubert, G; Winkelmann, BR; Schleiffer, T; März, W; Winkler, R; Gök, R; Klein, B; Schneider, S; Boehm, BO.
Prevalence, predictors, and consequences of unrecognized diabetes mellitus in 3266 patients scheduled for coronary angiography.
Am Heart J. 2003; 145(2):285-291
Doi: 10.1067/mhj.2003.134
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- BACKGROUND: Previous population-based studies have reported a proportion of undiagnosed diabetes in the range between 25% and 50%. However, data on undiagnosed diabetes in a high-risk population, such as patients scheduled for coronary angiography, are lacking. Therefore, we sought to determine prevalence, predictors, and consequences of unrecognized diabetes in patients scheduled for coronary angiography. METHODS: This analysis involved 3266 patients scheduled for coronary angiography who have been enrolled in the Ludwigshafen Risk and Cardiovascular Health study. RESULTS: Five hundred fifty-six patients (17.0%) had known diabetes. Another 486 patients with previously unrecognized diabetes (17.9%) were diagnosed in the remaining 2710 presumed nondiabetic subjects. Therefore, 486 (46.6%) of a total of 1042 patients with diabetes were previously undiagnosed, raising the diabetic proportion of enrolled patients to 31.9%. In half of the newly diagnosed patients with diabetes, the disease was detectable only by use of glucose challenge. Independent predictors of unrecognized type 2 diabetes were C-reactive protein >5 mg/L, arterial hypertension, body mass index >30 kg/m(2), age >or=65 years, and a positive family history of diabetes. Compared with nondiabetic subjects, patients with unrecognized type 2 diabetes showed a significantly increased risk for coronary artery disease (odds ration [OR] 1.7, 95% CI 1.3-2.3) and multivessel disease (OR 1.4, 95% CI 1.1-1.8), and a borderline association with myocardial infarction (OR 1.2, 95% CI 1.0-1.5). Oral glucose challenge was not superior to fasting glucose in predicting this increased cardiovascular risk. CONCLUSION: In half of the patients scheduled for coronary angiography, diabetes was previously unrecognized. In a high-risk population of patients scheduled for coronary angiography, screening for diabetes should be performed routinely to initiate timely preventive efforts.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Blood Glucose - analysis
- Coronary Angiography - analysis
- Coronary Disease - radiography
- Diabetes Complications - radiography
- Diabetes Mellitus - diagnosis
- Diabetes Mellitus, Type 2 - complications
- Diabetic Angiopathies - radiography
- Female - radiography
- Glucose Tolerance Test - radiography
- Humans - radiography
- Male - radiography
- Middle Aged - radiography
- Multivariate Analysis - radiography
- Myocardial Infarction - radiography
- Odds Ratio - radiography
- Prevalence - radiography
- Regression Analysis - radiography