Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Huber, R; Nauck, M; Lüdtke, R; Scharnagl, H.
Effects of one week juice fasting on lipid metabolism: a cohort study in healthy subjects.
Forsch Komplementarmed Klass Naturheilkd. 2003; 10(1):7-10
Doi: 10.1159/000069901
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- Co-Autor*innen der Med Uni Graz
- Scharnagl Hubert
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- Abstract:
- OBJECTIVE: We investigated the effects of a popular modified juice fasting program on lipid metabolism. VOLUNTEERS AND METHODS: 5 healthy, nonobese, male volunteers fasted for 8 days. Daily energy intake was limited to 150-300 kcal/d solely as carbohydrates (vegetable and fruit drinks). Physical activity was maintained as before. At baseline, on days 2, 3, and 8 during fasting, and on days 2 and 8 after fasting, serum lipids, lipoproteins, and insulin were investigated. RESULTS: Juice fasting resulted in bi-phasic changes: Until day 2 and 3 triacylglycerols (TG), very low-density lipoprotein apolipoprotein B (VLDL apo B), and insulin decreased by 52, 51, and 65% respectively, while nonesterified fatty acids (NEFA), low-density lipoprotein (LDL) apo B, and LDL cholesterol increased by 363, 38, and 35%. Between day 3 and 8 NEFA increased; TG and insulin increased as well, but remained below baseline values, and LDL cholesterol normalized. After 8 days juice fasting significant changes (p < 0.05) compared to the baseline were found only for free cholesterol (-10%), phospholipids (-14%), apo AI (-9%), apo AII (-11%), insulin (-42%), C-peptide (-57%), and NEFA (+535%, p = 0.0001). Total cholesterol decreased by 9% (n.s.) after 8 days. One week after the ending of fasting all parameters returned to normal. CONCLUSION: Contrary to total fasting and fasting with limited physical activity, 8 days juice fasting without limitation of physical activity results in a decrease of free cholesterol and an only initial increase of LDL cholesterol. After 8 days insulin, TG, and VLDL are still lower than at baseline, however, they have increased compared to the initial phase, probably counterregulatory to a further increase of NEFA.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Apolipoproteins - blood
- Beverages - blood
- Cholesterol - blood
- Cholesterol, VLDL - blood
- Cohort Studies - blood
- Energy Intake - blood
- Exercise - blood
- Fasting - blood
- Fatty Acids, Nonesterified - blood
- Fruit - blood
- Humans - blood
- Insulin - blood
- Ketone Bodies - urine
- Lipid Metabolism - urine
- Lipids - blood
- Male - blood
- Triglycerides - blood
- Vegetables - blood
- Find related publications in this database (Keywords)
- fasting
- vegetable juices
- cholesterol
- nonesterified fatty acids
- lipoproteins
- insulin