Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ljungberg, MC; Asuni, A; Pearce, J; Dayanandan, R; März, W; Hoffmann, MM; Bertrand, P; Siest, G; Rupniak, HT; Anderton, BH; Huettinger, M; Lovestone, S.
Apolipoprotein E (apoE) uptake and distribution in mammalian cell lines is dependent upon source of apoE and can be monitored in living cells.
Neurosci Lett. 2003; 341(1):69-73
Doi: 10.1016%2FS0304-3940%2803%2900064-8
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- As part of investigations of the cellular uptake of apolipoprotein E (apoE) relevant to Alzheimer's disease we have found that different preparations of apoE are handled differently by cells expressing the LDL-receptor. Comparing recombinant, cellular and native apoE, complexed with different preparations of lipid we find that only cellular and native apoE enter a vesicular compartment. Some, but not all of these apoE containing vesicles are lysosomes. In order to further examine the intracellular fate of apoE we demonstrate that apoE-Enhanced green fluorescent protein chimeric protein can be taken up from medium by recipient cells and tracked within these cells for extended periods.
- Find related publications in this database (using NLM MeSH Indexing)
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- Humans - metabolism
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- Find related publications in this database (Keywords)
- apolipoprotein E
- tau
- beta VLDL
- enhanced green fluorescent protein
- Alzheimer's disease
- uptake
- apolipoprotein