Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Man, Y; Mannion, C; Kuhls, E; Moinfar, F; Bratthauer, GL; Albores-Saavedra, J; Tavassoli, FA.
Allelic losses at 3p and 11p are detected in both epithelial and stromal components of cervical small-cell neuroendocrine carcinoma.
Appl Immunohistochem Mol Morphol. 2001; 9(4):340-345
Doi: 10.1097%2F00022744-200112000-00009
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Moinfar Farid
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- Abstract:
- Microdissected epithelial and stromal cells from 15 cervical small-cell carcinoma patients and 9 healthy control subjects were assessed for loss of heterozygosity with polymorphic DNA markers at chromosomes 3p and 11p. Among malignant lesions assessed with 7 markers at 3p, 21 allelic losses were detected from 193 informative samples. Of losses, 20 were in epithelial and 1 was in normal-appearing stromal cells. Among losses in epithelial cells, 16 were from 44 samples informative for 3 markers within 3p21.2-p14.2 (0.36 loss/sample), whereas only 4 were from 54 samples informative for 4 markers outside the region (0.09 loss/sample), suggesting a "hot spot" of genetic alterations within 3p21.2-p14.2. Among malignant lesions assessed with 2 markers within 11p14-p12, 15 losses were seen in 52 informative samples. Of losses, 10 were in epithelial and 5 were in normal-appearing stromal cells. Of 10 epithelial samples showing losses within 11p14-p12, 8 also displayed losses within 3p21.2-p14.2, suggesting a concurrent involvement of these loci in tumor development or progression. The five losses in stromal cells were in four cases that showed no loss in epithelial cells with same markers, suggesting that stromal cells might play initiative roles in tumor development.
- Find related publications in this database (using NLM MeSH Indexing)
- Alleles -
- Carcinoma, Neuroendocrine - etiology
- Carcinoma, Small Cell - etiology
- Case-Control Studies - etiology
- Chromosomes, Human, Pair 11 - etiology
- Chromosomes, Human, Pair 3 - etiology
- Epithelial Cells - pathology
- Female - pathology
- Genetic Markers - pathology
- Humans - pathology
- Loss of Heterozygosity - physiology
- Stromal Cells - pathology
- Uterine Cervical Neoplasms - etiology
- Find related publications in this database (Keywords)
- cervical carcinoma
- fragile histidine triad (FHIT) gene
- loss of heterozygosity
- microdissection
- Wilms' tumor 1 (WT-1) gene