Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Popper, HH; Pailer, S; Wurzinger, G; Feldner, H; Hesse, C; Eber, E.
Expression of adhesion molecules in allergic lung diseases.
Virchows Arch. 2002; 440(2):172-180
Doi: 10.1007/s004280100507
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Popper Helmuth
- Co-Autor*innen der Med Uni Graz
- Eber Ernst
- Hesse Christian
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- Abstract:
- Endothelial adherence and migration of leukocytes into tissue is mediated by different sets of adhesion molecules. The expression of these sets might not only preselect the types of leukocytes that enter the inflammatory sites, but also activate these leukocytes, induce adherence to epithelial cells, and cause the release of cytokines. Atopic asthma, extrinsic allergic alveolitis, and sarcoidosis as examples of immunologic lung diseases were investigated for the expression of adhesion molecules. Bronchial biopsies in chronic obstructive lung disease (COPD) and resected lung tissue of juvenile emphysema were chosen for controls. Immunohistochemistry was done on sections from bronchial and transbronchial biopsies and on smears from bronchoalveolar lavage cells. In all three types of immune disorders, lymphocytes expressed the integrins alpha4/beta1 (VLA4) and ICAM3, whereas lymphocytes in COPD bronchitis and in emphysema controls were unreactive. Eosinophils in atopic asthma bronchitis in contrast to COPD bronchitis also expressed both VLA4 and ICAM3. The expression of VCAM1 on endothelial cells was only seen in atopic asthma and was related to disease activity. The expression of other adhesion molecules was nonspecific. Expression of VCAM1 on endothelial cells and its ligand VLA4 on lymphocytes and eosinophils seems to be a specific event in atopic asthma. Expression of VLA4 and ICAM3 on lymphocytes, however, might be a specific event in all three immune reactions.
- Find related publications in this database (using NLM MeSH Indexing)
- Alveolitis, Extrinsic Allergic - immunology
- Antigens, CD - immunology
- Antigens, Differentiation - immunology
- Asthma - immunology
- Bronchi - metabolism
- Bronchoalveolar Lavage - metabolism
- Bronchoalveolar Lavage Fluid - cytology
- Cell Adhesion Molecules - biosynthesis
- Endothelium - metabolism
- Eosinophils - metabolism
- Humans - metabolism
- Immunohistochemistry - metabolism
- Integrin alpha4beta1 - metabolism
- Integrins - biosynthesis
- Intercellular Adhesion Molecule-1 - metabolism
- Lymphocyte Function-Associated Antigen-1 - metabolism
- Macrophage-1 Antigen - metabolism
- Pulmonary Emphysema - immunology
- Receptors, Lymphocyte Homing - biosynthesis
- Respiratory Mucosa - metabolism
- Sarcoidosis - immunology
- Find related publications in this database (Keywords)
- adhesion molecules
- integrins
- selectins
- atopic asthma
- sarcoidosis
- extrinsic allergic alveolitis
- COPD bronchitis