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Selected Publication:
Schulze-Bauer, CAJ; Regitnig, P; Holzapfel, GA.
Mechanics of the human femoral adventitia including the high-pressure response.
Am J Physiol Heart Circ Physiol. 2002; 282(6):H2427-H2440
Doi: 10.1152/ajpheart.00397.2001
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- Co-authors Med Uni Graz
- Regitnig Peter
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- Abstract:
- Adventitial mechanics were studied on the basis of adventitial tube tests and associated stress analyses utilizing a thin-walled model. Inflation tests of 11 nonstenotic human femoral arteries (79.3 +/- 8.2 yr, means +/- SD) were performed during autopsy. Adventitial tubes were separated anatomically and underwent cyclic, quasistatic extension-inflation tests using physiological pressures and high pressures up to 100 kPa. Associated circumferential and axial stretches were typically <20%, indicating "adventitiosclerosis." Adventitias behaved nearly elastically for both loading domains, demonstrating high tensile strengths (>1 MPa). The anisotropic and strongly nonlinear mechanical responses were represented appropriately by two-dimensional Fung-type stored-energy functions. At physiological pressure (13.3 kPa), adventitias carry ~25% of the pressure load in situ, whereas their circumferential and axial stresses were similar to the total wall stresses (~50 kPa in both directions), supporting a "uniform stress hypothesis." At higher pressures, they became the mechanically predominant layer, carrying >50% of the pressure load. These significant load-carrying capabilities depended strongly on circumferential and axial in-vessel prestretches (mean values: 0.95 and 1.08). On the basis of these results, the mechanical role of the adventitia at physiological and hypertensive states and during balloon angioplasty was characterized.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Biomechanics -
- Elasticity -
- Femoral Artery - anatomy and histology
- Humans - anatomy and histology
- Mathematics - anatomy and histology
- Pressure - anatomy and histology
- Stress, Mechanical - anatomy and histology
- Tensile Strength - anatomy and histology
- Find related publications in this database (Keywords)
- human artery
- elasticity
- stress-strain relationship
- mechanical properties