Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mannweiler, S; Tsybrovskyy, O; Regauer, S.
The flow cytometric DNA index can predict the presence of lymph node metastases in invasive ductal breast carcinoma.
APMIS. 2002; 110(7-8):580-586
Doi: 10.1034%2Fj.1600-0463.2002.1007810.x
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mannweiler Sebastian
- Co-Autor*innen der Med Uni Graz
- Regauer Sigrid
- Tsybrovskyy Oleksiy
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- Abstract:
- Axillary lymph node (LN) dissection is an important staging procedure for invasive ductal breast carcinoma (IDC), but causes elevated morbidity. Reliable preoperative prediction of metastases is at present not possible. We investigated whether flow cytometric analysis of primary IDC can correctly predict the presence of LN metastases at the time of primary diagnosis. In 341 primary IDC, DNA index (DI) in absolute values, S-phase fraction (SPF), size of the primary tumor, tumor grade (G), estrogen/progesterone receptors (ER/PR) expression and age were analysed and correlated with the axillary LN status with the aim of correctly predicting the LN status. No predictive value was identified for S-phase fraction (SPF), tumor grade, or ER/PR expression. The DI correlated statistically with LN status in all patients. A practically useful association was, however, only observed in 37 women aged 45-58 years with an IDC >2 cm diameter: a DI >1.44 predicted the presence of LN metastases at the time of operation with a specificity of 100% and a sensitivity of 89%, a negative predictive value of 91% and a positive predictive value of 100%. Determination of the absolute values of the DI may be a useful adjunct to sentinel LN preparation when predicting the axillary LN status and may spare some women the morbidity associated with axillary LN dissection.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Aged -
- Aged, 80 and over -
- Breast Neoplasms - metabolism
- Carcinoma, Ductal, Breast - metabolism
- DNA, Neoplasm - metabolism
- Female - metabolism
- Flow Cytometry - metabolism
- Humans - metabolism
- Lymph Nodes - metabolism
- Lymphatic Metastasis - metabolism
- Middle Aged - metabolism
- Predictive Value of Tests - metabolism
- Receptors, Estrogen - metabolism
- Receptors, Progesterone - metabolism
- Sensitivity and Specificity - metabolism
- Find related publications in this database (Keywords)
- axillary lymph node dissection
- DNA index
- ductal breast carcinoma
- flow cytometric analysis
- sentinel lymph node
- S-phase fraction