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Selected Publication:
Neumeister, P; Pixley, FJ; Xiong, Y; Xie, H; Wu, K; Ashton, A; Cammer, M; Chan, A; Symons, M; Stanley, ER; Pestell, RG.
Cyclin D1 governs adhesion and motility of macrophages.
Mol Biol Cell. 2003; 14(5):2005-2015
Doi: 10.1091/mbc.02-07-0102
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- Leading authors Med Uni Graz
- Neumeister Peter
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- Abstract:
- The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein, thereby promoting cell-cycle progression. Cyclin D1 is overexpressed in hematopoetic and epithelial malignancies correlating with poor prognosis and metastasis in several cancer types. Because tumor-associated macrophages have been shown to enhance malignant progression and metastasis, and cyclin D1-deficient mice are resistant to oncogene-induced malignancies, we investigated the function of cyclin D1-/- bone marrow-derived macrophages. Cyclin D1 deficiency increased focal complex formation at the site of substratum contact, and enhanced macrophage adhesion, yielding a flattened, circular morphology with reduced membrane ruffles. Migration in response to wounding, cytokine-mediated chemotaxis, and transendothelial cell migration of cyclin D1-/- bone marrow-derived macrophages were all substantially reduced. Thus, apart from proliferative and possible motility defects in the tumor cells themselves, the reduced motility and invasiveness of cyclin D1-/- tumor-associated macrophages may contribute to the tumor resistance of these mice.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Adhesion - physiology
- Cell Movement - physiology
- Chemotaxis - physiology
- Cyclin D1 - deficiency
- Macrophage Colony-Stimulating Factor - metabolism
- Macrophages - metabolism
- Mice - metabolism