Medizinische Universität Graz - Research portal
Selected Publication:
Liebmann, PM; Hofer, D; Absenger, A; Zimmermann, P; Weiss, U; Porta, S; Schauenstein, K.
Computer-controlled flushing for long-term cannulation in freely moving rats.
J Pharmacol Toxicol Methods. 1995; 34(4):211-214
Doi: 10.1016/1056-8719(95)00096-8
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Liebmann-Holzmann Peter
- Co-authors Med Uni Graz
- Porta Sepp
- Schauenstein Konrad
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- Abstract:
- An in vivo long-term perfusion system is presented, which is based on automated, computer-controlled high-frequency heparin (10 U/mL) flushing of the cannula inserted into the tail artery of freely moving rats. The short flushing intervals as achieved with this system guarantee stable conditions throughout an experiment of several days, and reduce blood clotting and the infiltration of fibroblasts. In addition, a specially developed software enables the periodical application of test substances into the blood stream under time-controlled conditions over long periods. The system can be used continuously to follow up blood parameters in single animals without significant elicitation of stress-sensitive plasma catecholamines for up to 12 days.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Catecholamines - blood
- Catheterization - methods
- Infusions, Intravenous - methods
- Male - methods
- Microcomputers - methods
- Perfusion - instrumentation
- Rats - instrumentation
- Rats, Sprague-Dawley - instrumentation
- Time Factors - instrumentation
- Find related publications in this database (Keywords)
- Freely Moving Rats
- Long-Term Cannulation
- Chronic Blood-Sampling
- Stress-Free
- Plasma-Catecholamines
- Computer-Controlled Flushing
- Perfusion-System