Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hilbe, W; Kühr, T; Apfelbeck, U; Fridrik, M; Seewann, H; Stöger, M; Linkesch, W; Pont, J; Baldinger, C; Hartner, E; Bernhart, M; Geissler, D; Krieger, O; Lang, A; Lin, W; Ludwig, H; Duba, C; Greil, R; Gast, G; Thaler, J.
Dose escalation of ara-c may improve response rates in a subgroup of chronic myeloid leukemia patients with poor response to interferon-alpha and low-dose ara-C.
LEUK LYMPHOMA. 2002; 42(6): 1283-1288.
Doi: 10.1080%2F10428190127503
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Apfelbeck Ute
- Linkesch Werner
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- Abstract:
- The present analysis was performed to evaluate the impact of cytosine arabinoside (ara-C) dose escalation on hematological and cytogenetic responses in patients with chronic myelogenous leukemia (CML) who failed to respond to low-dose ara-C (LD ara-C) at a dose of 10 mg/m2/d over 10 days per month and interferon-alpha (IFNalpha, 3.5 MU/d). Following the same administration schedule, dose escalation of ara-C to 15 and 20 mg/m2/d 1-10 was performed in 36 of 119 patients (30%) due to inadequate hematological response and/or disease progression. As a result, improvement of hematological and cytogenetic responses was achieved in 22 (61%) and nine (25%) patients, respectively. Escalated ara-C dose levels were usually well tolerated, although some patients experienced deterioration of preexisting side effects. Our results support the critical role of ara-C dose towards a better disease control in CML.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Child - therapeutic use
- Child, Preschool - therapeutic use
- Cytarabine - administration and dosage
- Female - administration and dosage
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- Interferon-alpha - administration and dosage
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- Find related publications in this database (Keywords)
- chronic myeloid leukemia
- low-dose ara-C
- interferon-alpha
- dose escalation