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Schippinger, W; Regitnig, P; Bauernhofer, T; Ploner, F; Hofmann, G; Krippl, P; Wehrschütz, M; Lax, S; Carney, W; Neumann, R; Wernecke, KD; Samonigg, H.
The course of serum HER-2/neu levels as an independent prognostic factor for survival in metastatic breast cancer.
ONCOL REP. 2004; 11(6): 1331-1336.
Doi: 10.3892/or.11.6.1331
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PubMed
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- Leading authors Med Uni Graz
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Schippinger Walter
- Co-authors Med Uni Graz
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Bauernhofer Thomas
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Hofmann Guenter
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Krippl Peter
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Ploner Ferdinand
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Regitnig Peter
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Samonigg Hellmut
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Wehrschütz Martin
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- Abstract:
- The purpose of this study was to determine the impact of serum HER-2/neu level dynamics during the course of disease and treatment on the prognosis of patients with metastatic breast cancer. Two thousand and thirty-eight serum samples collected sequentially after disease relapse in 286 patients with metastatic breast cancer were measured by Bayer Immuno 1 trade mark assay retrospectively for serum HER-2/neu (cut-off level 15 ng/ml). One hundred and five patients (37%) presented with serum HER-2/neu continuously =15 ng/ml after disease recurrence, 71 (25%) had continuously elevated levels and 110 patients (38%) had both non-elevated and elevated values in the course of metastatic breast cancer. Patients with continuously elevated serum HER-2/neu levels had a significantly poorer survival after disease recurrence compared to patients with continuously or temporarily non-elevated serum HER-2/neu values (log-rank test: p<0.001). Including the number of palliative antitumor therapies and therapy response in Cox regression analysis, serum HER-2/neu dynamics revealed to be an independent prognostic factor for survival. In conclusion, 63% of 286 patients with metastatic breast cancer demonstrated either continuously or temporarily elevated serum HER-2/neu levels. Decrease of elevated serum HER-2/neu to levels =15 ng/ml and levels continuously =15 ng/ml during the course of disease correlated significantly with longer survival.
- Find related publications in this database (using NLM MeSH Indexing)
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Adult -
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Aged -
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Aged, 80 and over -
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Antineoplastic Agents - therapeutic use
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Breast Neoplasms - blood
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Disease Progression - blood
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Enzyme-Linked Immunosorbent Assay - blood
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Female - blood
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Gene Amplification - blood
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Humans - blood
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Immunoenzyme Techniques - blood
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In Situ Hybridization, Fluorescence - blood
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Middle Aged - blood
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Neoplasm Recurrence, Local - blood
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Prognosis - blood
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Receptor, erbB-2 - blood
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Retrospective Studies - blood
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Survival Rate - blood
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Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
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breast cancer
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serum HER-2/neu
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prognostic factors