Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Constantinou Deltas, C; Bashiardes, E; Patsalis, PC; Hadjimarcou, M; Kroisel, PM; Ioannou, PA; Roses, AD; Lee, JE.
Complete coding sequence, exon/intron arrangement and chromosome location of ZNF45, a KRAB-domain-containing gene.
Cytogenet Cell Genet. 1996; 75(4):230-233
Doi: 10.1159/000134490
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Kroisel Peter
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- Abstract:
- Zinc finger genes represent a large multigene family present in mammalian and other genomes. A subgroup of these genes contain a conserved motif, the KRAB domain, at the NH2-terminal region, which was recently shown to posses a potent transcriptional repression activity. For one such gene, ZNF45, we determined the complete coding sequence, along with the exon/intron arrangement and the splice junctions. Exon 2 codes exclusively for the KRAB-A element of 42 amino acids, and exon 4 contains the 19 zinc finger repeats. In addition, we generated an EST (expressed sequence tag) from the 3'-end of ZNF45 that we used for polymerase chain reaction screening of a P1-derived genomic library. We isolated a 65-kb clone that was used for localizing this gene on chromosome 19q13.2 by fluorescence in situ hybridization.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
- Base Sequence -
- Chromosome Mapping -
- Chromosomes, Human, Pair 19 - genetics
- Consensus Sequence - genetics
- Exons - genetics
- Genes - genetics
- Humans - genetics
- In Situ Hybridization, Fluorescence - genetics
- Introns - genetics
- Kruppel-Like Transcription Factors - genetics
- Molecular Sequence Data - genetics
- Multigene Family - genetics
- Protein Structure, Tertiary - genetics
- Repressor Proteins - genetics
- Sequence Alignment - genetics