Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moinfar, F; Regitnig, P; Tabrizi, AD; Denk, H; Tavassoli, FA.
Expression of androgen receptors in benign and malignant endometrial stromal neoplasms.
VIRCHOWS ARCHIV. 2004; 444(5): 410-414.
Doi: 10.1007/s00428-004-0981-9
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Moinfar Farid
- Co-Autor*innen der Med Uni Graz
- Denk Helmut
- Regitnig Peter
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- Abstract:
- Several studies have shown that endometrial stromal neoplasms express estrogen and progesterone receptors (ER, PR). To our knowledge, the presence or absence of androgen receptors (AR) in these rare uterine neoplasms has not been investigated. Tumors ( n=20)-3 endometrial stromal nodules, 14 low-grade endometrial stromal sarcomas (ESS, low grade), and 3 high-grade endometrial sarcomas (undifferentiated endometrial sarcoma, UES)-were studied. Immunohistochemical analyses for ER, PR, and AR were performed on formalin-fixed, paraffin-embedded archival material. Positive immunoreactions for ER and PR were observed in 14 (70%) and 17 (85%) cases, respectively. Furthermore, 9 cases (45%) were positive for AR. Among 17 ESS and UES cases, 7 (41%) revealed positivity for AR. Two of three benign stromal nodules were also positive for AR. Moreover, one of the three high-grade sarcomas (undifferentiated endometrial sarcoma) was negative for both ER and PR, but showed positive reaction for AR. In summary, ARs are expressed in 45% of endometrial stromal neoplasms. In addition to determination of ER and PR, the results of immunohistochemical examination of AR in these rare uterine tumors may have some impact on the postoperative management of the patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Count -
- Endometrial Neoplasms - metabolism
- Female - metabolism
- Fluorescent Antibody Technique, Indirect - metabolism
- Humans - metabolism
- Receptors, Androgen - metabolism
- Receptors, Estrogen - metabolism
- Receptors, Progesterone - metabolism
- Sarcoma, Endometrial Stromal - metabolism
- Tumor Markers, Biological - metabolism
- Find related publications in this database (Keywords)
- endometrial stromal tumors
- androgen receptor
- estrogen receptor
- progesterone receptor
- immunohistochemistry