Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pizzichetta, MA; Canzonieri, V; Massarut, S; Gloghini, A; Trevisan, G; Veronesi, A; Soyer, HP.
Pigmented mammary Paget's disease mimicking melanoma.
MELANOMA RES 2004 14: S13-S15.
Doi: 10.1097%2F00008390-200404000-00017
(- Case Report)
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Soyer Hans Peter
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- Abstract:
- Our case of pigmented mammary Paget's disease simulated melanoma clinically and dermoscopically. Histologically, the lesion was characterized by microscopic features similar to those seen in malignant melanoma and, to a lesser extent, in Bowen's disease (intra-epidermal squamous cell carcinoma). Immunohistochemical studies demonstrated that the tumor cells were positive for keratins (Cam 5.2+MNF 116) and AE1-AE3 and negative for HMB-45 and S-100 proteins. In conclusion clinical and dermoscopic examination cannot reliably distinguish melanoma from epithelial pre-neoplastic or neoplastic disease, therefore the differentiation of pigmented Paget's disease from superficial spreading of melanoma and Bowen's disease is based on histopathologic integrated with immunohistochemical criteria.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Breast Neoplasms - diagnosis
- Diagnosis, Differential - diagnosis
- Female - diagnosis
- Humans - diagnosis
- Keratin - metabolism
- Melanoma - diagnosis
- Paget's Disease, Mammary - diagnosis
- Skin Neoplasms - diagnosis
- Find related publications in this database (Keywords)
- pigmented mammary Paget's disease
- dermoscopic features
- melanoma