Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Czermak, C; Lehofer, M; Renger, H; Wagner, EM; Lemonis, L; Rohrhofer, A; Schauenstein, K; Liebmann, PM.
Dopamine receptor D3 mRNA expression in human lymphocytes is negatively correlated with the personality trait of persistence.
J Neuroimmunol. 2004; 150(1-2):145-149
Doi: 10.1016/j.jneuroim.2004.01.009
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- Co-authors Med Uni Graz
- Liebmann-Holzmann Peter
- Schauenstein Konrad
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- Abstract:
- It has been proposed that neurotransmitter receptor expression in peripheral immune cells reflects expression of these receptors in the brain. To test this "peripheral marker hypothesis", we compared mRNA expression of the dopamine receptors D3 (DRD3) and D4 (DRD4) in peripheral blood lymphocytes (PBL) to personality traits assessed with the Temperament and Character Inventory (TCI) in 50 healthy and unmedicated Caucasian individuals. A shared variance of at least 17% (p=0.016) between DRD3 mRNA expression in PBL and the personality trait of persistence was found. As personality traits have been generally assumed polygenic with a single gene accounting for rarely more than 1-2% of observed variance in a trait, this result lends further support to the peripheral marker hypothesis for DRD3 mRNA expression in PBL. It may also suggest a significant role for the DRD3 in the neurobiology of persistence and point to an interesting link between personality and functioning of the immune system.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Analysis of Variance -
- Exploratory Behavior - physiology
- Female - physiology
- Genetic Markers - physiology
- Humans - physiology
- Lymphocyte Subsets - metabolism
- Male - metabolism
- Personality - genetics
- Personality Inventory - statistics and numerical data
- RNA, Messenger - biosynthesis
- Receptors, Dopamine D2 - biosynthesis
- Receptors, Dopamine D3 - biosynthesis
- Receptors, Dopamine D4 - biosynthesis
- Reverse Transcriptase Polymerase Chain Reaction - biosynthesis
- Statistics, Nonparametric - biosynthesis
- Find related publications in this database (Keywords)
- human
- personality
- receptors
- dopamine
- lymphocytes
- polymerase chain reaction
- RNA
- messenger