Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fazekas, C; Enzinger, C; Wallner, M; Kischka, U; Greimel, E; Kapeller, P; Stix, P; Pieringer, W; Fazekas, F.
Depressive symptoms following herpes simplex encephalitis--an underestimated phenomenon?
Gen Hosp Psychiatry. 2006; 28(5):403-407
Doi: 10.1016/j.genhosppsych.2006.05.004
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- Führende Autor*innen der Med Uni Graz
- Fazekas Christian
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fazekas Franz
- Greimel Elfriede Renate
- Kapeller Peter
- Pieringer Walter
- Stix Peter
- Wallner-Blazek Mirja
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- Abstract:
- Objective: In view of the herpes simplex virus' neurotropism for the limbic system and the temporal lobe, little is known about potential negative effects of this necrotizing encephalitis on affective functioning and health-related quality of life (HRQoL) after recovery. We therefore set out to explore an association between herpes simplex virus encephalitis (HSE) and both depressive symptoms and HRQoL. Methods: A structured telephone interview was conducted in 26 subjects (F/M=10/16; age at follow-up, 49.3 +/- 15.0 years; range, 29-80) at a mean time interval of 5.2 +/- 3.1 years (range, 1-11) after their initial diagnosis of HSE. WHO-5 Well-Being Index (WHO-5) was used as screening instrument for depression, and Short Form-12 was used as HRQoL instrument. We also determined the spatial extent of morphologic abnormalities on magnetic resonance imaging (MRI). Results: Ten of the interviewees (38.5%) had a WHO-5 score below 13, which is considered indicative of a depressive disorder. Accordingly, concerning their HRQoL, patients felt more impaired by affective than by physical symptoms. MRI ratings and WHO-5 score were not correlated. Conclusions: While this pilot study does not allow to establish a causal relationship with focal brain damage, findings suggest both a high frequency of depressive symptoms and a low quality of life with respect to mental health following HSE. These results should be confirmed by a prospective trial. (c) 2006 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Blood-Brain Barrier - physiology
- Brain - pathology
- Brain Damage, Chronic - diagnosis
- Cerebral Cortex - pathology
- Cross-Sectional Studies -
- Depression - diagnosis
- Disability Evaluation -
- Dominance, Cerebral - physiology
- Encephalitis, Herpes Simplex - diagnosis
- Female -
- Follow-Up Studies -
- Frontal Lobe - pathology
- Humans -
- Interview, Psychological -
- Interviews as Topic -
- Leukoencephalitis, Acute Hemorrhagic - diagnosis
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Neurologic Examination -
- Quality of Life - psychology
- Statistics as Topic -
- Temporal Lobe - pathology
- Find related publications in this database (Keywords)
- herpes simplex encephalitis
- long-term follow-up
- screening
- depression
- health-related quality of life