Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Blaukovitsch, M; Halbwedl, I; Kothmaier, H; Gogg-Kammerer, M; Popper, HH.
Sarcomatoid carcinomas of the lung--are these histogenetically heterogeneous tumors?
Virchows Arch. 2006; 449(4):455-461
Doi: 10.1007/s00428-006-0256-8
[Oral Communication]
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- Führende Autor*innen der Med Uni Graz
- Popper Helmuth
- Co-Autor*innen der Med Uni Graz
- Halbwedl Iris
- Kothmaier Hannelore
- Petzmann Susanne
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- Abstract:
- Sarcomatoid carcinomas (SC) of the lung are a heterogeneous group of nonsmall cell lung carcinomas (NSCLC) containing a sarcoma or sarcoma-like component. SC may represent an epithelial neoplasm undergoing divergent tissue differentiation originating from a single clone. Epithelial-mesenchymal transition (EMT) best describes the origin of the spindle and giant cells. We aimed to define chromosomal aberrations within the subgroups of SC and if EMT does play a role in SC. Twenty-two SC were investigated by chromosomal comparative genomic hybridization (CGH). Immunohistochemical staining was performed with antibodies for E-cadherin, Vimentin, c-Fos, c-Jun, Snail, TGFbeta1, Notch1, beta-catenin, Glycogen synthase kinase 3beta (GSK3beta), and Fascin. Gains occurred more frequently than losses (70.5 vs 29.5%). The shortest regions of overlap were gains on chromosomes 8q and 7 followed by 1q, 3q, and 19, supporting the common origin of the different subtypes of SC. The immunohistochemical staining suggests that the sarcomatoid components of SC might have undergone EMT, not triggered by the signaling pathways Notch1, Snail, and TGFbeta1, but probably initiated by an upregulation of c-Jun and a consecutive overexpression of Vimentin and Fascin. The Wnt-pathway was not deregulated because combined membrane and cytoplasmic reactivity for beta-catenin and GSK3beta was observed.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Non-Small-Cell Lung - chemistry
- Carcinosarcoma - chemistry
- Chromosome Aberrations - chemistry
- DNA, Neoplasm - analysis
- Humans - analysis
- Lung Neoplasms - chemistry
- Nucleic Acid Hybridization - chemistry
- Spectral Karyotyping - chemistry
- Tumor Markers, Biological - analysis
- Variation (Genetics) - analysis
- Find related publications in this database (Keywords)
- lung carcinomas
- sarcomatoid carcinomas
- comparative genomic hybridization
- CGH
- epithelial mesenchymal transition
- immunohistochemistry
- notch
- c-Jun
- vimentin
- fascin