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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Channick, RN; Olschewski, H; Seeger, W; Staub, T; Voswinckel, R; Rubin, LJ.
Safety and efficacy of inhaled treprostinil as add-on therapy to bosentan in pulmonary arterial hypertension.
J AMER COLL CARDIOL. 2006; 48(7): 1433-1437.
Doi: 10.1016/j.jacc.2006.05.070
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- Co-authors Med Uni Graz
- Olschewski Horst
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- Abstract:
- OBJECTIVES: This study evaluated the safety and efficacy of inhaled treprostinil as add-on therapy to oral bosentan in patients with pulmonary arterial hypertension (PAH). BACKGROUND: The addition of a long-acting prostacyclin analogue via the inhaled route might be a safe and effective strategy to optimize therapy in PAH patients on bosentan. METHODS: Twelve patients with symptomatic PAH despite bosentan received either 30 microg of inhaled treprostinil 4 times daily (n = 6) or 45 microg 4 times daily (n = 6), via an ultrasonic nebulizer. Six-min walk distance (6MWD), functional class, and hemodynamics were assessed at baseline and 12 weeks. RESULTS: One patient was excluded from analysis due to the subsequent finding of pulmonary capillary hemangiomatosis. In the remaining 11 patients, inhaled treprostinil was safe and well tolerated. Inhaled treprostinil was associated with an increase in 6MWD at 12 weeks (baseline 339 +/- 86, 12 week, 1 h post-inhalation 406 +/- 121 m, 67-m change, p = 0.01). An improvement in 6MWD of 49 m from baseline was noted during the trough period, just before inhalation of treprostinil (p = 0.009). The 6MWD improvement of at least 10% was noted in 1 of 6 patients receiving 30 microg versus 5 of 6 receiving 45 microg. Over 12 weeks, significant decreases were noted in mean pulmonary arterial pressure (-10%) and in pulmonary vascular resistance (-26%). Functional class improved from III to II in 9 of 11 patients. CONCLUSIONS: This trial suggests that inhaled treprostinil is safe, well tolerated, and associated with significant improvements in exercise capacity, functional class, and pulmonary hemodynamics in symptomatic patients with PAH on bosentan.
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- Administration, Inhalation -
- Administration, Oral -
- Adult -
- Aged -
- Antihypertensive Agents - administration and dosage
- Blood Pressure - drug effects
- Epoprostenol - administration and dosage
- Female - administration and dosage
- Humans - administration and dosage
- Hypertension, Pulmonary - drug therapy
- Lung - blood supply
- Male - blood supply
- Middle Aged - blood supply
- Severity of Illness Index - blood supply
- Sulfonamides - administration and dosage
- Treatment Outcome - administration and dosage
- Vascular Resistance - drug effects