Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tribl, GG; Asenbaum, S; Happe, S; Bonelli, RM; Zeitlhofer, J; Auff, E.
Normal striatal D2 receptor binding in idiopathic restless legs syndrome with periodic leg movements in sleep.
Nucl Med Commun. 2004; 25(1):55-60
Doi: 10.1097/01.mnm.0000109366.12233.f9
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Bonelli Raphael
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- Abstract:
- Dopaminergic treatment is very effective in restless legs syndrome (RLS) and periodic leg movements in sleep (PLMS). However, neuroreceptor imaging studies that addressed altered striatal dopaminergic function have given controversial results. In this present study, 14 patients with idiopathic RLS (iRLS) and PLMS with a good response to dopaminergic and non-dopaminergic treatment and ten healthy sex- and age-matched controls were investigated off-medication by using 123I-IBZM and SPECT. RLS symptoms and sleep disturbances were evaluated using three nights of polysomnography, the Pittsburgh Sleep Quality Index, and the International RLS Study Group (IRLSSG) rating scale. The patients presented with sleep disturbances, a high PLMS index (56.2 +/- 33.1 per h), and severe RLS symptoms during SPECT (IRLSSG rating scale 23.1 +/- 8.0), and showed no significant differences in striatal to frontal IBZM binding to D2 receptors compared to controls (ratio striatum/frontal cortex, right side 1.60 +/- 0.10 vs 1.63 +/- 0.08, P = 0.35, NS; left side 1.61 +/- 0.11 vs 1.63 +/- 0.08, P = 0.51, NS). These findings show normal function of striatal D2 receptors in successfully treated patients with iRLS and PLMS. Dopaminergic and non-dopaminergic pretreatment does not appear to change striatal D2 receptor binding as compared to healthy controls. Structures other than striatal D2 receptors are discussed as possible causes of the treatment effects in RLS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Aged -
- Aged, 80 and over -
- Aging - metabolism
- Anticonvulsants - therapeutic use
- Benzamides - diagnostic use
- Corpus Striatum - metabolism
- Dopamine Antagonists - therapeutic use
- Female - therapeutic use
- Humans - therapeutic use
- Male - therapeutic use
- Middle Aged - therapeutic use
- Nocturnal Myoclonus Syndrome - diagnosis
- Pyrrolidines - diagnostic use
- Radiopharmaceuticals - diagnostic use
- Receptors, Dopamine D2 - metabolism
- Restless Legs Syndrome - diagnosis
- Severity of Illness Index - diagnosis
- Find related publications in this database (Keywords)
- restless legs syndrome
- D-2 dopamine receptor binding
- I-123-IBZM
- single photon emission computerized tomography (SPECT)
- sleep disorders