Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mossböck, G; Weger, M; Moray, M; Renner, W; Haller-Schober, EM; Mattes, D; Schmut, O; Wegscheider, B; El-Shabrawi, Y.
TNF-alpha promoter polymorphisms and primary open-angle glaucoma.
EYE. 2006; 20(9): 1040-1043.
Doi: 10.1038/sj.eye.6702078
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- Leading authors Med Uni Graz
- Mossböck Georg
- Co-authors Med Uni Graz
- El-Shabrawi Yosuf
- Haller-Schober Eva-Maria
- Mattes Dietmar
- Renner Wilfried
- Schmut Otto
- Weger Martin
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- Abstract:
- Purpose Primary open-angle glaucoma (POAG) is a multifactorial optic neuropathy with a strong hereditary component. Recent studies suggested a role for tumour necrosis factor-alpha (TNF-alpha) in the pathogenesis of POAG. The purpose of the present study was to investigate a hypothesized association between the TNF-alpha -308G > A and -238G > A gene polymorphisms and the presence of POAG in a Caucasian population. Methods The present case-control study comprised 114 unrelated patients with POAG and 228 healthy control subjects, matched for age and gender. Genotyping of the TNF-alpha -308G > A and -238G > A polymorphisms was performed using polymerase chain reaction. Results Allelic frequencies and genotype distributions of both the TNF-alpha -308G > A and -238G > A gene polymorphisms did not significantly differ between patients with POAG and control subjects. Presence of the TNF-alpha -308A- allele was associated with an odds ratio (OR) of 0.96 for POAG, whereas an OR of 0.52 was found among carriers of the TNF-alpha -238A-allele. Conclusion Our data suggest that none of the investigated TNF-alpha gene polymorphisms is a major risk factor among Caucasian patients with POAG.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Case-Control Studies -
- Female -
- Gene Frequency -
- Genetic Predisposition to Disease -
- Genotype -
- Glaucoma, Open-Angle - genetics
- Humans -
- Male -
- Middle Aged -
- Polymerase Chain Reaction - methods
- Polymorphism, Genetic -
- Promoter Regions, Genetic - genetics
- Tumor Necrosis Factor-alpha - genetics
- Find related publications in this database (Keywords)
- open-angle glaucoma
- tumour necrosis factor-alpha
- genetic polymorphism