Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wolf, G; Aigner, RM; Schaffler, G; Schwarz, T; Krippl, P.
Pathology results in [18F]fluorodeoxyglucose positron emission tomography of the thyroid gland.
Nucl Med Commun. 2003; 24(12):1225-1230
Doi: 10.1097/01.mnm.0000104643.79626.a1
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Aigner Reingard
- Krippl Peter
- Schaffler Gottfried
- Schwarz Thomas
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- Abstract:
- The aim of this retrospective study was to evaluate pathologically increased uptake of [18F]fluorodeoxyglucose (18F-FDG) in positron emission tomography (PET) results of the thyroid gland. Results of 18F-FDG PET and [99mTc]pertechnetate scintigraphy of the thyroid gland are shown, compared to each other and discussed. In a retrospective study 16 patients underwent whole-body 18F-FDG PET and [99mTc]pertechnetate scintigraphy of the thyroid gland within 3 weeks. In addition, an examination of the thyroid gland by using ultrasound and laboratory tests was carried out. The 18F-FDG PET studies were carried out on a dedicated whole-ring PET scanner. Eight patients had a pathological FDG uptake in the thyroid and a cold nodule in [99mTc]pertechnetate scintigraphy of the thyroid gland (in 7/8 cases histology showed malignancy). Five patients had an inhomogeneous FDG uptake in the thyroid gland and were suspected of thyroiditis in 18F-FDG PET (in 3/5 cases thyroiditis was confirmed). Three patients had an especially low FDG uptake compared to normal physiological FDG uptake (no malignancy). Results from studies using 18F-FDG represent a growing body of evidence showing the differentiation between malignant and benign disease: we saw many pathological results in the thyroid gland. High uptake of 18F-FDG in the thyroid gland suggests possible malignancy. Thyroiditis can only be suspected based upon the results of 18F-FDG PET. We conclude that 18F-FDG PET has a potential clinical impact for detecting possible malignant lesions of the thyroid gland, but further studies, in which a higher number of patients are evaluated, are necessary.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Female -
- Fluorodeoxyglucose F18 - diagnostic use Fluorodeoxyglucose F18 - pharmacokinetics
- Humans -
- Male -
- Middle Aged -
- Radiopharmaceuticals - diagnostic use Radiopharmaceuticals - pharmacokinetics
- Reproducibility of Results -
- Sensitivity and Specificity -
- Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid Gland - radionuclide imaging
- Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid Neoplasms - radionuclide imaging
- Tomography, Emission-Computed - methods
- Find related publications in this database (Keywords)
- F-18-FDG PET
- positron emission tomography
- [Tc-99m]pertechnetate scintigraphy
- thyroid
- thyroiditis