Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pattison, LR; Kotter, MR; Fraga, D; Bonelli, RM.
Apoptotic cascades as possible targets for inhibiting cell death in Huntington's disease.
J Neurol. 2006; 253(9):1137-1142
Doi: 10.1007/s00415-006-0198-8
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- Führende Autor*innen der Med Uni Graz
- Bonelli Raphael
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- Abstract:
- Huntington's disease (HD) is a devastating autosomal dominant disorder characterized by progressive motor and neuropsychological symptoms. Evidence implicating the apoptotic cascades as a possible cause for the neurodegeneration seen in HD has directed researchers toward investigating therapeutic treatments targeting caspases and other proapoptotic factors. Cellular and murine models, which have demonstrated that caspase-mediated cleavage could be the cause for the neurodegeneration seen in HD, have evoked more research investigating the possible inhibition of apoptosis in HD. In particular, minocycline, a tetracycline-derived antibiotic that has been shown to increase survival in transgenic mouse models of HD, exhibits a neuroprotective feature in HD and demonstrates an anti-inflammatory as well as an anti-microbial effect by inhibiting microglial activation known to cause apoptosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Apoptosis - drug effects
- Humans - drug effects
- Huntington Disease - drug therapy
- Minocycline - therapeutic use
- Models, Biological - therapeutic use
- Neural Inhibition - drug effects
- Find related publications in this database (Keywords)
- Huntington's disease
- apoptosis
- neurodegeneration
- neuroprotection
- minocycline