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Martinez-Gamboa, L; Brezinschek, HP; Burmester, GR; Dörner, T.
Immunopathologic role of B lymphocytes in rheumatoid arthritis: rationale of B cell-directed therapy.
AUTOIMMUN REV. 2006; 5(7): 437-442. Doi: 10.1016/j.autrev.2006.02.004
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Co-authors Med Uni Graz: Brezinsek Hans-Peter
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Abstract:: Although the immunopathogenesis of rheumatoid arthritis (RA) remains unclear, recent advances have paved the way for new therapies, such as anti-cytokine and cell-directed therapies. Here, B cells have re-gained interest concerning the pathogenesis of a number of autoimmune diseases after observing that patients with RA and non-Hodgkin lymphoma, who received anti-CD20 therapy leading to B cell depletion, demonstrated remarkable improvements. The underlying modes of action appear to be related to B cell functions, such as deletion of memory B cells, interruption of immune activation, antigen-presentation and production of inflammatory cytokines. In many RA patients, synovial extrafollicular germinal centers develop, where B cells play an intimate role in local inflammation and the generation of memory B cells and plasma cells. These local processes lead to activation of the immune system and ultimately to joint destruction in RA. Recent data demonstrating the clinical value of B cell depletion in refractory RA patients substantiate the notion that B cells are important players in the pathogenesis of the disease. Future studies should clarify which functions are affected by B cell depletion, providing the promise of new avenues to patient-tailored therapies.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Arthritis, Rheumatoid - immunology; B-Lymphocytes - immunology; Humans - immunology
Find related publications in this database (Keywords): B lymphocytes; rheumatoid arthritis; B cell-directed therapies