Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Legat, FJ; Jaiani, LT; Wolf, P; Wang, M; Lang, R; Abraham, T; Solomon, AR; Armstrong, CA; Glass, JD; Ansel, JC.
The role of calcitonin gene-related peptide in cutaneous immunosuppression induced by repeated subinflammatory ultraviolet irradiation exposure.
Exp Dermatol. 2004; 13(4):242-250
Doi: 10.1111/j.0906-6705.2004.00185.x
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Legat Franz
- Co-authors Med Uni Graz
- Wolf Peter
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Ultraviolet (UV) light is an effective treatment for skin disorders like psoriasis in which the cutaneous neurosensory system may have a pathogenic role. In this study, we examined the possibility that UV modulation of the cutaneous neurosensory system and calcitonin gene-related peptide (CGRP) may contribute to local immunosuppression mediated by repeated subinflammatory UV irradiation. Our results indicated that exposure of hairless mice to subinflammatory UV three times weekly for 4 weeks significantly increased the number of epidermal nerve fibers (ENFs) immunoreactive for CGRP without altering the total number of ENFs. The skin content of CGRP as measured by enzyme-linked immunosorbent assay was also significantly increased after exposure to this dose of UV. These effects were most apparent 1 day after the last UV exposure and declined 1 week after UV. The role of CGRP in UV-induced immunosuppression of contact hypersensitivity was then examined. Our results indicated that UV suppression of epicutaneous 2,4-dinitro-1-fluorobenzene (DNFB) sensitization could be significantly inhibited by a systemically administered CGRP receptor antagonist. A broad-spectrum sunscreen applied before UV exposure inhibited increased cutaneous CGRP and blocked immunosuppression. These findings support a role for CGRP in the local immunosuppression caused by chronic, repeated subinflammatory UV exposure.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcitonin Gene-Related Peptide - antagonists & inhibitors
- Calcitonin Gene-Related Peptide - immunology
- Calcitonin Gene-Related Peptide - metabolism
- Calcitonin Gene-Related Peptide - pharmacology
- Female -
- Immune Tolerance - radiation effects
- Mice -
- Mice, Hairless -
- Nerve Fibers - metabolism
- Nerve Growth Factor - metabolism
- Peptide Fragments - pharmacology
- Skin - immunology
- Skin - innervation
- Skin - metabolism
- Skin - radiation effects
- Substance P - metabolism
- Ultraviolet Rays - adverse effects
- Find related publications in this database (Keywords)
- broad-spectrum sunscreen
- CGRP(8-37)
- contact hypersensitivity reaction
- epidermal nerve fibers
- neuropeptides