Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schicho, R; Holzer, P; Lippe, IT.
Gastric enteric neurones that respond to luminal injury.
NEUROGASTROENTEROL MOTIL. 2004; 16 Suppl 1(7): 129-132.
Doi: 10.1111/j.1743-3150.2004.00488.x
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- Leading authors Med Uni Graz
- Schicho Rudolf
- Co-authors Med Uni Graz
- Holzer Peter
- Lippe Irmgard Theresia
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- Abstract:
- Challenge of the rat gastric mucosa with HCl stimulates intrinsic neurones in the myenteric plexus of the stomach as demonstrated by immunohistochemical detection of c-Fos. In multiple labelling experiments of whole-mounts and sections of the gastric corpus we determined the chemical code of the stimulated neurones and investigated further whether neural pathways involving capsaicin-sensitive afferents, cholinergic neurones or the vagal system contribute to the stimulation of these neurones. Intragastric (IG) administration of 0.5 m HCl caused c-Fos expression in 12% of myenteric neurones, whereas IG saline failed to induce c-Fos. All stimulated neurones stained for nitric oxide synthase (NOS), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY), but not for choline acetyltransferase (ChAT). Fibres coexpressing NOS/VIP/NPY were found predominantly in the external muscle layer and the muscularis mucosae of the stomach wall. Pretreatment with capsaicin or hexamethonium, combination of both pretreatments or vagotomy reduced HCl-induced c-Fos expression by 54%, 66%, 63% and 68%, respectively. The data indicate that mucosal acid challenge of the stomach stimulates inhibitory motor neurones in the myenteric plexus and that capsaicin-sensitive afferents as well as cholinergic neurones participate in the neuronal stimulation probably via a vago-vagal reflex.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Enteric Nervous System - cytology Enteric Nervous System - physiology
- Gastric Mucosa - drug effects Gastric Mucosa - injuries
- Genes, fos - drug effects
- Hydrochloric Acid - toxicity
- Neurons - cytology Neurons - drug effects Neurons - physiology
- Stomach - injuries Stomach - innervation
- Find related publications in this database (Keywords)
- c-Fos
- capsaicin
- mucosal acid challenge
- multiple labelling
- neurochemical coding