Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Holzer, P.
Gastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targets.
EXPERT OPIN THER TARGETS. 2004; 8: 107-123.
Doi: 10.1517/14728222.8.2.107
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Holzer Peter
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- Abstract:
- Functional bowel disorders (FBDs) are defined by symptoms of gastrointestinal (GI) dysfunction, discomfort and pain in the absence of a demonstrable organic cause. Since the prevalence of FBDs, particularly functional dyspepsia and irritable bowel syndrome, can be as high as 20%, FBDs represent a significant burden in terms of direct healthcare and productivity costs. There is emerging evidence that the discomfort and pain experienced by many FBD patients is due to persistent hypersensitivity of primary afferent neurons, which may develop in response to infection, inflammation or other insults. This concept identifies vagal and spinal sensory neurons as important targets for novel therapies of GI hyperalgesia. Sensory neuron-specific targets can be grouped into three categories: receptors and sensors at the peripheral nerve terminals, ion channels relevant to nerve excitability and conduction and transmitter receptors. Particular therapeutic potential is attributed to targets that are selectively expressed by afferent neurons, such as the transient receptor potential channel TRPV1, acid-sensing ion channels and tetrodotoxin-resistant Na + channels.
- Find related publications in this database (using NLM MeSH Indexing)
- Analgesics - administration and dosage
- Colonic Diseases, Functional - drug therapy
- Drug Delivery Systems - methods
- Humans - methods
- Neurons, Afferent - drug effects
- Pain - drug therapy
- Research Support, Non-U.S. Gov't - drug therapy
- Find related publications in this database (Keywords)
- 5-HT3 and 5-HT4 receptors
- abdominal pain
- add-sensing ion channels
- functional bowel disorders (FBDs)
- functional dyspepsia
- gastrointestinal (GI) hyperalgesia
- irritable bowel syndrome (IBS)
- purinoceptors
- sensory neurons
- tetrodotoxin-resistant sodium