Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schallmoser, K; Rosin, C; Vormittag, R; Brunner, M; Dunkler, D; Pabinger, I; Panzer, S.
Specificities of platelet autoantibodies and platelet activation in lupus anticoagulant patients: a relation to their history of thromboembolic disease.
Lupus. 2006; 15(8):507-514
Doi: 10.1191/0961203306lu2341oa
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- Leading authors Med Uni Graz
- Schallmoser Katharina
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- Abstract:
- Lupus anticoagulants (LA) prolong in vitro phospholipid-dependent coagulation tests, but are associated with thromboembolic disease (TE). However, a subgroup of individuals with LA has no TE, and it is therefore desirable to distinguish those at risk for TE from those without. Whether platelets have a primary role in the development of TE is not clear yet. We determined platelet autoantibodies to identify a specific platelet target which is associated with platelet activation in 97 patients with a long history of detectable LA, 65 patients with TE (LA/TE+), and 32 individuals without TE (LA/TE-). Thrombocytopenia was more common in the LA/TE- than in the LA/TE+ group (P < 0.05). Both groups had platelet antibodies, but the frequency of antibodies was lower in LA/TE+ than LA/TE- patients (P < 0.01), who had higher antibody titres against glycoprotein IIb/IIIa and glycoprotein Ib/IX (P < 0.05). Also, their platelets were more activated, as determined by PAC-1 binding (P < 0.01). These differences were also noted if patients with arterial thrombosis were evaluated separately. These findings in LA/TE- individuals were similar to those in patients with chronic autoimmune thrombocytopenia. However, there was no autoantibody target identifiable to distinguish between LA/TE- from LA-TE+ individuals. We therefore conclude that the presence of platelet antibodies, even if associated with platelet activation, is not sufficient to dispose LA patients to thromboembolic disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Antiphospholipid Syndrome - immunology
- Autoantibodies - immunology
- Blood Coagulation Tests - immunology
- Blood Platelets - immunology
- Child - immunology
- Female - immunology
- Humans - immunology
- Lupus Coagulation Inhibitor - immunology
- Middle Aged - immunology
- Platelet Activation - immunology
- Platelet Membrane Glycoproteins - immunology
- Random Allocation - immunology
- Thrombocytopenia - immunology
- Thromboembolism - immunology
- beta 2-Glycoprotein I - immunology
- Find related publications in this database (Keywords)
- lupus anticoagulant
- platelet activation
- platelet autoantibodies
- thromboembolic disease