Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Grammer, TB; Renner, W; von Karger, S; Boehm, BO; Winkelmann, BR; Maerz, W.
The angiotensin-I converting enzyme I/D polymorphism is not associated with type 2 diabetes in individuals undergoing coronary angiography. (The Ludwigshafen Risk and Cardiovascular Health Study).
Mol Genet Metab. 2006; 88(4):378-383
Doi: 10.1016/j.ymgme.2006.01.008
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- Führende Autor*innen der Med Uni Graz
- März Winfried
- Co-Autor*innen der Med Uni Graz
- Renner Wilfried
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- Abstract:
- The deletion (D) allele of the angiotensin-I converting enzyme (ACE) is associated with higher ACE activity and has been implicated only recently in the pathogenesis of type 2 diabetes in Caucasian subjects. We have studied the ACE I/D polymorphism in 1054 patients with type 2 diabetes and in 2251 individuals without type 2 diabetes in Caucasians persons undergoing coronary angiography. Further parameters of glucose metabolism (fasting glucose, HbA1c, insulin, C-peptide, pro-insulin, and pancreatic beta-cell function) were analyzed according to the ACE I/D genotype in a subgroup of 2000 individuals in whom an oral glucose challenge was performed. The genotypes ACE II, ID, DD occurred at similar frequencies in patients with type 2 diabetes mellitus (21.0, 50.8, and 28.3%, respectively) compared to non-diabetic individuals (23.3, 49.2, and 27.5%, respectively). There was no association of the ACE D allele with all type 2 diabetes mellitus (OR 1.16, 95%CI, 0.94-1.43), nor with known (OR 1.28, 95% CI, 0.99-1.68) or newly diagnosed diabetes (OR 1.00, 95% CI, 0.75-1.32). These findings were not materially altered when we adjusted for age and gender, cardiovascular risk factors and anti-diabetic or cardiovascular medication. Further the ACE D-allele was not associated with angiographic coronary heart disease or myocardial infarction. The ACE I/D genotype is not associated with type 2 diabetes mellitus, glucose metabolism, coronary heart disease, or myocardial infarction.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Alleles -
- Case-Control Studies -
- Coronary Angiography -
- Coronary Disease - genetics
- Diabetes Mellitus, Type 2 - genetics
- Female - genetics
- Genome, Human - genetics
- Genotype - genetics
- Glucose Tolerance Test - genetics
- Humans - genetics
- Leukocytes - chemistry
- Male - chemistry
- Middle Aged - chemistry
- Myocardial Infarction - genetics
- Peptidyl-Dipeptidase A - genetics
- Polymorphism, Genetic - genetics
- Find related publications in this database (Keywords)
- type 2 diabetes mellitus
- angiotensin-I converting enzyme
- genetics
- glucose
- coronary heart disease
- myocardial infarction