Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Koestenberger, M; Gallistl, S; Cvirn, G; Roschitz, B; Rehak, T; Leschnik, B; Muntean, W.
Combined effects of melagatran and eptifibatide on platelet aggregation inhibition but not thrombin generation inhibition.
BLOOD COAGULAT FIBRINOL. 2004; 15(2): 131-137.
Doi: 10.1097%2F00001721-200403000-00004
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Koestenberger Martin
- Co-Autor*innen der Med Uni Graz
- Acham-Roschitz Birgit
- Cvirn Gerhard
- Gallistl Siegfried
- Leschnik Bettina
- Muntean Eugen
- Rehak Thomas
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- Abstract:
- The aim of our study was to investigate the combined in vitro effects of melagatran and eptifibatide on platelet aggregation and thrombin generation under low and high coagulant challenge in tissue-factor-activated, platelet-rich plasma. Increasing amounts of melagatran dose-dependently decreased prothrombin fragment 1.2 and activated factor X values, and dose-dependently prolonged the lag phase until the onset of platelet aggregation. Eptifibatide exerted a dose-dependent anti-aggregating effect under both high and low coagulant challenge. The combination of melagatran and eptifibatide resulted in significant additive prolongation of the lag phase until the onset of platelet aggregation, which was more pronounced under low coagulant challenge. Under low, but not under high, coagulant challenge, the combination of melagatran and eptifibatide had a significant additive inhibitory effect on platelet aggregation. No additive effects on decreasing prothrombin fragment 1.2 and activated factor X values were observed with combined administration of the drugs.The present study demonstrates the additive effect of melagatran and eptifibatide on platelet aggregation inhibition and on prolongation of the lag phase until the onset of platelet aggregation.
- Find related publications in this database (using NLM MeSH Indexing)
- Azetidines -
- Benzylamines -
- Dose-Response Relationship, Drug -
- Drug Synergism -
- Factor Xa - analysis
- Glycine - analogs and derivatives
- Humans - analogs and derivatives
- Peptide Fragments - analysis
- Peptides - pharmacology
- Platelet Aggregation - drug effects
- Platelet Aggregation Inhibitors - pharmacology
- Prothrombin - analysis
- Thrombin - biosynthesis
- Thromboplastin - pharmacology
- Find related publications in this database (Keywords)
- melagatran
- eptifibatide
- platelet aggregation
- thrombin generation