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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schimpl, G; Uray, E; Ratschek, M; Höllwarth, ME.
Constipation and intestinal neuronal dysplasia type B: a clinical follow-up study.
J PEDIAT GASTROENTEROL NUTR 2004 38: 308-311.
Doi: 10.1097%2F00005176-200403000-00015
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- Leading authors Med Uni Graz
- Schimpl Guenther
- Co-authors Med Uni Graz
- Höllwarth Michael
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- Abstract:
- OBJECTIVE: Intestinal neuronal dysplasia type B (IND B) is one of the gastrointestinal motility disorders with a defined malformation of the parasympathetic submucous and myenteric ganglia. The clinical presentation of IND B is variable, ranging from intestinal obstruction in the neonatal period to acute or chronic constipation in childhood. METHODS: Between 1993 and 1996, 105 patients (49 females and 56 males) were treated for constipation, and in all of them an IND type B was confirmed histopathologically. Twenty-two neonates, 42 infants to 6 months of age (38% of them were premature, and 5% had additional malformations), and 41 patients to the age of 4 years were included in this study.All 105 patients had been treated conservatively. Treatment consisted of diet in all patients, cisapride in 70% of them, laxatives in 52%, and repeated anal dilatations in 12% of the patients. The mean duration of their treatment lasted from 3 months to 10 months (mean, 6 months). RESULTS: The clinical follow-up 5 to 9 years later in 89 of the 108 (85%) patients showed daily defecation in 80% of them and every second day in 14% of them. Only 5 (6%) patients experience recurrent constipation, which responds well to diet and laxatives. CONCLUSIONS: In young patients, constipation related to IND B can be treated successfully by conservative treatment regimens, including diet, laxatives, and prokinetic drugs.
- Find related publications in this database (using NLM MeSH Indexing)
- Age of Onset -
- Cathartics - therapeutic use
- Child, Preschool - therapeutic use
- Cisapride - therapeutic use
- Constipation - drug therapy
- Defecation - drug effects
- Female - drug effects
- Follow-Up Studies - drug effects
- Gastrointestinal Agents - therapeutic use
- Humans - therapeutic use
- Infant - therapeutic use
- Infant, Newborn - therapeutic use
- Intestinal Diseases - diet therapy
- Intestines - innervation
- Male - innervation
- Myenteric Plexus - abnormalities
- Recurrence - abnormalities
- Submucous Plexus - abnormalities
- Find related publications in this database (Keywords)
- conservative treatment
- constipation
- intestinal neuronal dysplasia
- rectal suction biopsy