Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Müller, T; Langner, C; Fuchsbichler, A; Heinz-Erian, P; Ellemunter, H; Schlenck, B; Bavdekar, AR; Pradhan, AM; Pandit, A; Müller-Höcker, J; Melter, M; Kobayashi, K; Nagasaka, H; Kikuta, H; Müller, W; Tanner, MS; Sternlieb, I; Zatloukal, K; Denk, H.
Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis.
HEPATOLOGY. 2004; 39(4): 963-969.
Doi: 10.1002/hep.20108
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- Führende Autor*innen der Med Uni Graz
- Denk Helmut
- Müller Thomas
- Co-Autor*innen der Med Uni Graz
- Langner Cord
- Zatloukal Kurt
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- Abstract:
- Patients with Wilson's disease (WD), Indian childhood cirrhosis (ICC), and idiopathic copper toxicosis (ICT) develop severe liver disease morphologically characterized by ballooning of hepatocytes, inflammation, cytoskeletal alterations, and Mallory body (MB) formation, finally leading to mostly micronodular cirrhosis. The pathogenesis of MBs in copper toxicosis is still unresolved. Immunohistochemical analysis of MBs in different types of copper intoxication revealed that keratin, p62, and ubiquitin are integral components. Thus MBs associated with copper intoxication resemble those present in alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH). p62 is a multifunctional immediate early gene product that, on the one hand, is involved in stress-induced cell signaling (particularly that of oxidative stress) by acting as an adapter protein linking receptor-interacting protein (RIP) with the atypical protein kinase C. On the other hand, p62 binds with high affinity to polyubiquitin and ubiquitinated proteins. In conclusion, p62 accumulation in WD, ICC, and ICT and deposition in MBs indicates a central role of protein misfolding induced by oxidative stress in copper-induced liver toxicity. By sequestering potentially harmful misfolded ubiquitinated proteins as inert cytoplasmic inclusion bodies (e.g., as MBs), p62 may be a major player in an important cellular rescue mechanism in oxidative hepatocyte injury.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Child -
- Child, Preschool -
- Copper - metabolism
- Female - metabolism
- Hepatolenticular Degeneration - metabolism
- Humans - metabolism
- Immunohistochemistry - metabolism
- Inclusion Bodies - pathology
- Infant - pathology
- Liver - metabolism
- Liver Cirrhosis - metabolism
- Male - metabolism
- Nerve Degeneration - metabolism